en پریودنتولوژی Periodontology پژوهشي Research <p> Background: C-reactive protein (CRP) is an acute phase reactant and has been proved to be a<br>significant predictor of future cardiovascular events. Recent studies have demonstrated a correlation<br>between periodontitis and elevated CRP levels. However, comparison between the levels of CRP<br>in two main forms of periodontitis is ambiguous. This study aims at determining and comparing the<br>relative levels of serum CRP in aggressive and chronic periodontitis patients.<br>Materials and Methods: A total of 240 systemically healthy subjects were divided into three<br>groups of 80 based on having generalized aggressive periodontitis, chronic generalized periodontitis<br>and non-periodontitis (NP controls). Venous blood samples were collected for quantitative CRP<br>analysis using turbidimetric immunoassay.<br>Results: Mean CRP levels were significantly greater in both generalized aggressive periodontitis<br>(7.49±2.31 mg/l) and chronic generalized periodontitis (4.88±1.80 mg/l) groups as compared to NP<br>(0.68±0.23 mg/l) controls. Moreover, CRP levels were significantly higher in aggressive periodontitis<br>as compared to chronic periodontitis patients. Also, CRP levels positively correlated with the<br>amount of periodontal destruction as measured by probing depth and clinical attachment loss for<br>both chronic generalized periodontitis and generalized aggressive periodontitis.<br>Conclusion: Findings of the present study indicated that periodontitis should be of particular<br>concern in younger individuals, where elevated levels of CRP may contribute to early or more<br>rapid cardiovascular disease in susceptible patients. Thus, further research should be carried out<br>at a community level to ascertain these findings.</p><hr><p></p><p> <strong>Source:</strong> Dental Research Journal</p><p><a href="http://www.drj.mui.ac.ir/index.php/drj/article/view/899" target="_blank"><font color="#0000ff"> Full text</font></a> </p> C-reactive protein, cardiovascular disease, periodontitis 0 0 http://idai.ir/browse.php?a_code=A-10-32-383&slc_lang=en&sid=1 Rahul Chopra rahulchopra28@yahoo.com 10031947532846001612 10031947532846001612 Yes Departments of Periodontics and Preventive and Pediatric Dentistry, Government Dental College and Hospital, Rohtak, Haryana, India Sudhir R. Patil 10031947532846001613 10031947532846001613 No Department of Periodontics, K. L. E. Dental College and Hospital, Bangalore, Karnataka, India Shivani Mathur 10031947532846001614 10031947532846001614 No Preventive and Pediatric Dentistry, Government Dental College and Hospital, Rohtak, Haryana, India