en پریودنتولوژی Periodontology پژوهشي Research <p><strong> Background:</strong> Nanosized ceramics may represent a promising class of bone graft substitutes due<br>to their improved osseointegrative properties. Nanocrystalline Hydroxyapatite (NcHA) bind to<br>bone and stimulate bone healing by stimulation of osteoblast activity. The present study aims to<br>explore the clinical and radiographical outcome of NcHA bonegraft (Sybograf®) with collagen<br>membrane (Periocol®), in comparison with open flap debridement (OFD), in the treatment of<br>intrabony periodontal defects.<br><strong>Materials and Methods</strong>: A parallel-group, randomized, controlled clinical trial was designed to<br>conduct the study. Eighteen intrabony defects in 14 systemically healthy patients aged between 25<br>to 65 years were randomly assigned to test and control group. The plaque index, gingival index,<br>probing pocket depth (PPD), clinical attachment level (CAL), and gingival recession (REC) were<br>recorded at baseline, and were reevaluated at 6 months. In addition to this, radiographic bone fill<br>was assessed using digital software. At the test site, NcHA bone graft and collagen membrane was<br>placed, whereas at the control site, only OFD was done. Recall appointments were made at 7 days,<br>30 days, and then at 3 months and 6 months.<br><strong>Results:</strong> The data were subjected to statistical analysis using the Mann-Whitney ‘U’ Test and<br>Wilcoxon signed rank sum test. In the control group, the mean reduction of PPD was 3.22±1.09 mm<br>(P=0.007) and CAL gain was 2.77±1.09 mm (P=0.007). In the test group, the mean PPD reduction<br>of 4.33±0.5 mm (P=0.006) and mean gain in CAL was 3.77±0.66 mm (P=0.006) at 6 months.<br>The mean increase in REC was 0.55±0.72 mm (P=0.025) in test, and 0.44±0.52 mm (P=0.046) in<br>control group. The mean gain in radiographic defect fill was 2.07±0.67 mm (P=0.008) in test and<br>0.91±0.21 mm (P=0.007) in control group.<br><strong>Conclusion:</strong> The nanocrystalline hydroxyapatite bone graft in combination with collagen membrane<br>demonstrated clinical advantages beyond that achieved by OFD alone.</p><hr><p></p><p> <strong>Source:</strong> Dental Research Journal</p><p><a href="http://www.drj.mui.ac.ir/index.php/drj/article/view/897"><font color="#0000ff"> Full text</font></a> </p> Bone graft, collagen membrane, nanocrystalline hydroxyapatite, periodontal regeneration 0 0 http://idai.ir/browse.php?a_code=A-10-32-381&slc_lang=en&sid=1 Vijendra P. Singh dr.vijendra@hotmail.com 10031947532846001603 10031947532846001603 Yes Departments of Periodontology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, India Dilip G. Nayak 10031947532846001604 10031947532846001604 No Manipal College of Dental Sciences, Mangalore, India Ashita S. Uppoor 10031947532846001605 10031947532846001605 No Manipal College of Dental Sciences, Mangalore, India Dipen Shah 10031947532846001606 10031947532846001606 No A.M.C. Dental College, Ahmedabad, India