en بیماری های دهان Oral Medicine پژوهشي Research <p> <strong>Background:</strong> Recurrent Herpes Labialis (RHL) is one of most common infective vesiculoulcerative<br>lesions. according to some studies administration of topical and/or systemic zinc compositions has<br>been effective in treatment and prevention. This article aims to comparison of zinc level in healthy<br>subjects and RHL patients in acute and convalescent phases.<br><strong>Materials and Methods</strong>: This was a retrospective case – control study, carried on 80 individuals<br>(40 normal and 40 RHL patients) mean age=34.5 and 34.4, respectively. Saliva samples were taken<br>in patients in acute phase once and after healing of lesions in convalescent phase (averagely 21 days<br>later) and in normal individuals. Salivary zinc level concentration was measured by flame atomic<br>absorption spectrophotometer by dry digestion method. The results were statistically analyzed<br>with SPSS software by t-test (α=0.05).<br><strong>Results:</strong> Results showed that salivary zinc level in case group in acute and convalescent phases<br>were 160.8 ngr/ml and 205.7 ngr/ml respectivly and significant differences between them were existed<br>(P<0.05). Also significant differences were existed between zinc concentration in healthy subjects<br>and patient groups (in both phases) (P=.001 and .002 for acute and convalescent phases respectively).<br><strong>Conclusion:</strong> According to the results, zinc level is significantly lower in acute phase than in<br>convalescent phase and significantly lower in both phases compared to healthy individuals,so<br>determination of serum zinc level and prescribing zinc complement in low serum status has both<br>treatmental and preventive effects in RHL patients.</p><hr><p></p><p> <strong>Source:</strong> Dental Research Journal</p><p><a href="http://www.drj.mui.ac.ir/index.php/drj/article/view/890" target="_blank"><font color="#0000ff"> Full text</font></a></p> Acute phase, convalescent phase, recurrent herpes labialis, zinc level INTRODUCTION 0 0 http://idai.ir/browse.php?a_code=A-10-32-374&slc_lang=en&sid=1 Faezeh Khozeimeh 10031947532846001573 10031947532846001573 No Isfahan University of Medical Sciences, Isfahan, Iran Nasim Jafari nasimjafaripozve@yahoo.com 10031947532846001574 10031947532846001574 Yes School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran Ahmad Movahedian Attar 10031947532846001575 10031947532846001575 No School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran Sharam Jafari 10031947532846001576 10031947532846001576 No School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran Masoud Ataie 10031947532846001577 10031947532846001577 No School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran