fa In vivo biocompatibility of Resilon compared with gutta-percha in a pre-clinical model پاتولوزی دهان، فک و صورت Oral and Maxillofacial Pathology پژوهشي Research <b> Background</b>: The aim of this study was to investigate in vivo biocompatibility of Resilon, compared with gutta-percha, at short and long-term following implantation in a rat subcutaneous implantation model. <div>  <b>Materials and Methods:</b> Male Wistar rats were implanted subcutaneously with either Resilon or gutta-percha or were sham controls. Tissues were harvested at 8 days or 60 days after implantation and were evaluated histologically for inflammation and fibrous encapsulation. The severity of histologic injury, scored on a scale of 0-4 and quantitative analysis of the capsule wall thickness were determined for statistical analysis. Data were analyzed by Student t-test, one-way analysis of variance, Kruskal-Wallis or Mann-Whitney’s tests as appropriate. A value of P ≤ 0.05 was considered statistically significant. </div><div>  <b>Results: </b>No behavioral changes or visible signs of physical impairment were observed at 8 days or 60 days post-implantation. Histopathologic observation of the implanted sites at each timepoint showed that both Resilon and gutta-percha implants induced foreign body reaction, showing minimal to mild inflammatory reactions in most cases, which diminished significantly with time. Compared with gutta-percha, the capsule wall was thinner (P > 0.05) after Resilon implantation at day 8 and significantly (P = 0.01) thicker at day 60. In addition, capsule wall thickness showed a trend to increase with time after implantation in the Resilon groups (P > 0.05), opposed to the significant decrease (P = 0.016) observed after implantation in the gutta-percha groups, suggesting lesser long-term biocompatibility of Resilon. </div><div>  <b>Conclusion:</b> Our findings validate Resilon as an in vivo biocompatible material. However, our data suggest that long-term biocompatibility of Resilon, despite validated, is inferior to that of guttapercha control.</div><hr><p class="MsoNormal" style="text-align: left direction: ltr unicode-bidi: embed"><b>Source: </b>Dental Research Journal </p> <p class="MsoNormal" style="text-align: left direction: ltr unicode-bidi: embed"><a href="http://drj.mui.ac.ir/index.php/drj/article/view/1504" target="_blank"><font color="#0000ff">Full Text</font></a></p> Endodontic materials, gutta-percha, rat, Resilon, subcutaneous implantation 0 0 http://idai.ir/browse.php?a_code=A-10-32-3389&slc_lang=fa&sid=1 Miguel Cardoso miguelbcardoso@ gmail.com 100319475328460015565 100319475328460015565 Yes Departments of Experimental Pathology Rodrigo F. Marques 100319475328460015566 100319475328460015566 No Departments of Experimental Pathology Maria Francelina Lopes 100319475328460015567 100319475328460015567 No Experimental Surgery, Faculty of Medicine of the University of Coimbra, Rua Larga, 3004-504 António S. Cabrita 100319475328460015568 100319475328460015568 No Departments of Experimental Pathology João Miguel Santos 100319475328460015569 100319475328460015569 No Department of Dental Medicine, Stomatology and Maxillofacial Surgery, Faculty of Medicine of the University of Coimbra, Av. Bissaya Barret