fa The effect of adjunctive low-dose doxycycline and licorice therapy on gingival crevicular fluid matrix metalloproteinase-8 levels in chronic periodontitis پریودنتولوژی Periodontology پژوهشي Research <b> Background:</b> This study compared the effect of adjunctive low dose doxycycline and licorice on gingival crevicular fluid (GCF) matrix metalloproteinase-8 (MMP-8) levels in patients with chronic periodontitis. <div>  <b>Materials and Methods: </b>In this in vivo, experimental study 39 patients with mild to moderate chronic periodontitis were selected. Samples of GCF were collected from three deepest pockets and MMP-8 concentration was measured. Patients were divided into three groups (n = 13). Groups were treated with doxycycline, licorice and placebo. Sampling and measurement of MMP-8 was repeated after 6 weeks. Data was analyzed by t-paired and ANOVA test. P < 0.001 was considered significant.</div><div><b> Results:</b> The decrease in mean of MMP-8 concentration was higher in doxycycline and licorice group in comparison with the placebo group and the difference was statistically significant (P value < 0.001). The decrease in mean of MMP-8 concentration was higher in licorice group than doxycycline group, but the difference was not statistically significant. </div><div>  <b>Conclusion:</b> The present study showed that licorice extract can prevent the production of MMPs by host cells and can be as useful as antibiotics like doxycycline to cure periodontal and other inflammatory diseases. It must be added that no side-effects were observed in usage of licorice extract.</div><hr><p class="MsoNormal" style="text-align: left direction: ltr unicode-bidi: embed"><b>Source: </b>Dental Research Journal </p> <p class="MsoNormal" style="text-align: left direction: ltr unicode-bidi: embed"><a href="http://drj.mui.ac.ir/index.php/drj/article/view/1499" target="_blank"><font color="#0000ff">Full Text</font></a></p> Chronic periodontitis, doxycycline, gingival crevicular fluid, licorice, matrix 0 0 http://idai.ir/browse.php?a_code=A-10-32-3384&slc_lang=fa&sid=1 Shirin Zahra Farhad drsh.farhad@yahoo. com 100319475328460015540 100319475328460015540 Yes Department of Periodontics Atousa Aminzadeh 100319475328460015541 100319475328460015541 No Department of Oral Pathology Morvarid Mafi 100319475328460015542 100319475328460015542 No Department of Periodontics, Young Researchers Club Mehrdad Barekatain 100319475328460015543 100319475328460015543 No Department of Restorative Dentistry, Khorasgan Branch, Islamic Azad Dental School of Khorasgan Mohammad Naghney 100319475328460015544 100319475328460015544 No General Dentist, Private Practice, Isfahan, Iran Mohammad Reza Ghaffari 100319475328460015545 100319475328460015545 No Department of Periodontics