fa Histological assessment of intra-articular versus intra-peritoneal betamethasone L.A on tempromandibular joint arthritis in rat بیماری های دهان Oral Medicine پژوهشي Research <b> Background:</b> Pain and dysfunction of the tempromandibular joint (TMJ) are major clinical problems, especially, in arthritis. The aim of this study was to compare the effect of intra-articular (IA) versus intra-peritoneal (IP) injection of betamethasone long acting on TMJ arthritis in rat.<div><b> Materials and Methods:</b> In this experimental study, an inflammation in the left TMJ of 29 rats was induced by injection of complete Freund’s adjuvant. After 1 week, rats were divided into 5 groups: Group A: Rats of this group were not treated (n = 5) groups B, C: Rats were injected with a single dose of ½ mg/kg betamethasone L.A IA (n = 6) groups D, E: Rats received a single dose of ½ mg/kg betamethasone L.A IP (n = 6). Rats in groups B and D after 1 week, and in groups C, E and A, at 4 weeks after drug injection were sacrificed. Severity of inflammation was scored from 1 to 11 according to synovial hyperplasia, vascularity, fibrin deposits, and synovial adhesion. Results were analyzed by using Kruskal-Wallis and Mann-Whitney (P < 0/05 was considered significant). </div><div>  <b>Results:</b> Significant differences were existed between groups B, D (P = 0/004) and groups C, E (P = 0/002). The least severity of Inflammation and also evidence of resorbtion in condylar head was seen in group C. </div><div>  <b>Conclusion: </b>The best therapeutic response was seen with IA injection of betamethasone L.A in comparison with IP injection.</div><hr><p class="MsoNormal" style="text-align: left direction: ltr unicode-bidi: embed"><b>Source: </b>Dental Research Journal </p> <p class="MsoNormal" style="text-align: left direction: ltr unicode-bidi: embed"><a href="http://drj.mui.ac.ir/index.php/drj/article/view/1474" target="_blank"><font color="#0000ff">Full Text</font></a></p> Betamethasone L.A, histological assessment, intra-articular, intra-peritoneal, tempromandibular joint 0 0 http://idai.ir/browse.php?a_code=A-10-32-3363&slc_lang=fa&sid=1 Parichehr Ghalayani 100319475328460015471 100319475328460015471 No Torabinejad Dental Research Center and Department of Oral and Maxillofacial Disease, of Oral and Pathology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran Seid Mohammad Razavi 100319475328460015472 100319475328460015472 No Torabinejad Dental Research Center and Department of Oral and Pathology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran Fatemeh Babadi babadi.fatemeh@ yahoo.com 100319475328460015473 100319475328460015473 Yes Department of Oral and Maxillofacial Disease, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran Farimah Sardari 100319475328460015474 100319475328460015474 No Department of Oral and Maxillofacial Disease, School of Dentistry, Rafsanjan University of Medical Sciences, Rafsanjan, Iran