en پاتولوزی دهان، فک و صورت Oral and Maxillofacial Pathology پژوهشي Research <div class="para"><p><b>Background: </b> Peripheral giant cell lesion (PGCL) is a reactive process associated with a local irritating factor that shows low recurrence after treatment, especially if the irritating factor is eliminated. On the other hand, central giant cell lesion (CGCL) presents a variable clinical behavior ranging from slow and asymptomatic growth without recurrence to rapid, painful and recurrent growth. Our aim was to compare the immunoexpression of tumor necrosis factor-alpha (TNF-α) and transforming growth factor-beta (TGF-β) in CGCL and PGCL.</p></div><div class="para"><p><b>Methods: </b> Twenty CGCL and 20 PGCL were selected for analysis of the immunoexpression of TNF-α and TGF-β in multinucleated giant cells (MGC) and mononucleated cells (MC).</p></div><div class="para"><p><b>Results: </b> The PGCL showed lightly higher expression of TNF-α than CGCL. In comparison with PGCL, the CGCL showed higher expression of TGF-β in MC and MGC (<em>P</em> < 0.05) and in total cells (<em>P</em> < 0.05). Significant positive correlation was found between expressions of TGF-β and TNF-α in CGCL (<em>P</em> < 0.05).</p></div><div class="para"><p><b>Conclusions: </b> Our results suggest that, in CGCL, coordinated interactions between TGF-β and TNF-α may be important for osteoclastogenesis and bone resorption. PGCL occasionally cause bone resorption but to a lower extent, a fact that might be explained by the lower expression of TGF-β in these lesions.<hr></p><font size="3"><p dir="ltr"><strong>Source:</strong> Journal of Oral Pathology & Medicine</p><p><a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0714.2011.01075.x/abstract" target="_blank"><font color="#0000cc">Full text</font></a></p></font></div> central giant cell lesion,immunohistochemistry,peripheral giant cell lesion,TNF-α,TGF-β 0 0 http://idai.ir/browse.php?a_code=A-10-32-314&slc_lang=en&sid=1 Felipe Rodrigues de Matos 10031947532846001324 10031947532846001324 Yes Maiara de Moraes 10031947532846001325 10031947532846001325 No Cassiano Francisco Weege Nonaka 10031947532846001326 10031947532846001326 No Lélia Batista de Souza 10031947532846001327 10031947532846001327 No Roseana de Almeida Freitas 10031947532846001328 10031947532846001328 No