fa A randomized placebo-controlled double blind clinical trial of quercetin for treatment of oral lichen planus بیماری های دهان Oral Medicine پژوهشي Research <b> Background and aims</b>. Standard treatment of oral lichen planus (OLP) includes topical or systemic corticosteroids that have many adverse effects. A trend toward alternative natural or herbal drugs has attended recently. This study was conducted to evaluate the effect of quercetin in treatment of erosive-atrophic OLP. <div><b>Materials and methods.</b> Thirty patients participated in this randomized clinical trial from April 2010 to June 2010 (Trial Registration Number: NCT01375101). Patients were randomly allocated in two groups. Both groups received the standard treatment (dexamethasone mouthwash and nystatin suspension). Experimental group received oral 250 mg quercetin hydrate capsules (bid) and the control group received placebo capsules. The pain and severity of the lesions were recorded at the initial visit and the follow-ups. All recorded data were analyzed with chi-square, Mann-Whitney, t-test, Wilcoxon and Friedman tests using SPSS 11.5.</div><div><b> Results.</b> There were no significant differences between the two groups in severity of the lesions and pain in the follow-ups. According to the Friedman test, there was a significant reduction in pain (P = 0.01) and severity indices (P = 0.00) in the case group. These differences were not observed in the control group (P = 0.26, SI and P = 0.86, PI). No adverse effect of quercetin was reported. </div><div><b>Conclusion</b>. According to the results, no significant therapeutic effect can be considered for quercetin in treatment of OLP.</div><hr><p class="MsoNormal" style="text-align: left direction: ltr unicode-bidi: embed"><b>Source: </b>Journal of Dental Research, Dental Clinics, Dental Prospects </p> <p class="MsoNormal" style="text-align: left direction: ltr unicode-bidi: embed"><a href="http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/1480" target="_blank"><font color="#0000ff">Full Text</font></a></p> Clinical trial, lichen planus, quercetin, oral 0 0 http://idai.ir/browse.php?a_code=A-10-32-3308&slc_lang=fa&sid=1 Maryam Amirchaghmaghi 100319475328460015235 100319475328460015235 No Oral and Maxillofacial Diseases Research Center & Department of Oral Medicine, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran Zahra Delavarian 100319475328460015236 100319475328460015236 No Oral and Maxillofacial Diseases Research Center & Department of Oral Medicine, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran Mohammad Taghi Shakeri 100319475328460015238 100319475328460015238 No Department of Biostatistics & Epidemiology, School of Health, Mashhad University of Medical Science, Mashhad, Iran Pegah Mosannen Mozafari 100319475328460015239 100319475328460015239 No Oral and Maxillofacial Diseases Research Center & Department of Oral Medicine, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran Amir Hushang Mohammadpour 100319475328460015240 100319475328460015240 No Pharmacodynamy & Toxicology, School of Pharmacy & Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Fateme Farazi drfarazi@yahoo.com 100319475328460015241 100319475328460015241 Yes Department of Oral Medicine, School of Dentistry, North Khorasan University of Medical Sciences, Bojnurd, Iran Milad Iranshahy 100319475328460015242 100319475328460015242 No Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran