fa Effect of iranian propolis on salivary total antioxidant capacity in gamma-irradiated rats بیماری های دهان Oral Medicine پژوهشي Research <b> Background and aims</b>. The antioxidant and anti-inflammatory properties of propolis were studied. Since saliva contains antioxidants and radiotherapy of the head and neck mainly affects the saliva, salivary antioxidant defensive mechanism is compromised with oxidative stress produced by radiation therapy. Therefore, the aim of the present study was to investigate the effect of propolis on salivary total antioxidant capacity in irradiated rats.<div><b> Materials and methods. </b>The study was conducted on 28 rats, 7‒11 weeks of age (160±20 g), divided into four groups: saline with no radiation (S), saline and radiation (SR), propolis with no radiation (P) [400 mg/kg IP], propolis and radiation (PR) [400 mg/kg IP]. SP and PR were exposed to 15 Gy of gamma irradiation for 7 minutes and 39 seconds. The rats received intraperitoneal injections each day for 10 days, and their tongues and lips were daily examined for mucositis saliva sample were also taken three times on days 0, 6, and 10. </div><div><b>Results.</b> Mucositis incidence appeared to be delayed in the PR compared to the SR, and the severity was significantly higher in the SR compared to the PR. No significant alterations were observed in salivary antioxidant levels during the experiment, except the SR group in which a significant reduction was found.</div><div><b> Conclusion</b>. Propolis might reduce and delay radiation-induced mucositis in animal models it might be able to prevent the reduction in salivary antioxidant levels in irradiated rats as well.</div><hr><p class="MsoNormal" style="text-align: left direction: ltr unicode-bidi: embed"><b>Source: </b>Journal of Dental Research, Dental Clinics, Dental Prospects </p> <p class="MsoNormal" style="text-align: left direction: ltr unicode-bidi: embed"><a href="http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/659" target="_blank"><font color="#0000ff">Full Text</font></a></p> Antioxidant activity, propolis, saliva, radiation therapy 0 0 http://idai.ir/browse.php?a_code=A-10-32-3299&slc_lang=fa&sid=1 Sara Aghel 100319475328460015190 100319475328460015190 No Department of Oral Medicine, Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran Mahdi Pouramir 100319475328460015191 100319475328460015191 No Department of Biochemistry, Babol University of Medical Sciences, Babol, Iran Ali Akbar Moghadamnia 100319475328460015192 100319475328460015192 No Daruish Moslemi 100319475328460015193 100319475328460015193 No Department of Radiation Oncology, Babol University of Medical Sciences, Babol, Iran Tahere Molana 100319475328460015194 100319475328460015194 No Faculty of Dentistry, Mazandaran University of Medical Sciences, Babol, Iran Leila Ghassemi 100319475328460015195 100319475328460015195 No Mina Motalleb nejad mmotallebnejad@yahoo.com 100319475328460015196 100319475328460015196 Yes Cellular and Molecular Biology Research Center, Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran