fa Reduction of melatonin level in patients with type II diabetes and periodontal diseases پریودنتولوژی Periodontology پژوهشي Research <b> Background and aims</b>. Melatonin is a circulating hormone that is mainly released from the pineal gland. It possesses antioxidant, free-radical scavenging, and immune-enhancing properties. A growing number of studies reveal a complex role for melatonin in influencing various diseases, including diabetes and periodontal diseases. The aim of this study was to examine the possible links between salivary melatonin levels and type II diabetes and periodontal diseases. <div><b>Materials and methods</b>. A total of 30 type II diabetic patients, 30 patients with periodontal diseases, 30 type II diabetic patients with periodontal disease and 30 age- and BMI-matched controls were studied. The periodontal status was evaluated by the Community Periodontal Index (CPI). Salivary melatonin levels were determined by a commercial enzyme-linked immunosorbent assay (ELISA) kit.</div><div><b> Results</b>. The mean of salivary melatonin level was significantly lower in patients with either periodontitis or diabetes compared to healthy subjects (P < 0.05). Salivary melatonin concentration decreased in type II diabetic patients and periodontitis patients, and then decreased reaching the lowest levels in type II diabetic patients with periodontal disease. </div><div><b>Conclusion</b>. Based on the results of this study, it can probably be concluded that salivary level of melatonin has an important role in the pathogenesis of diabetes and periodontal diseases. It is also worth noting that this factor could probably be used as a pivotal biological marker in the diagnosis and possible treatment of these diseases, although further research is required to validate this hypothesis.</div><hr><p class="MsoNormal" style="text-align: left direction: ltr unicode-bidi: embed"><b>Source: </b>Journal of Dental Research, Dental Clinics, Dental Prospects </p> <p class="MsoNormal" style="text-align: left direction: ltr unicode-bidi: embed"><a href="http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/1162" target="_blank"><font color="#0000ff">Full Text</font></a></p> Iran, melatonin, periodontal disease, saliva, type II diabetes. 0 0 http://idai.ir/browse.php?a_code=A-10-32-3286&slc_lang=fa&sid=1 Hamidreza Abdosamadi 100319475328460015130 100319475328460015130 No Department of Oral Medicine, Dental Research Center, Hamadan University of Medical Sciences, Hamadan, Iran Mohammad Taghi Goodarzi 100319475328460015131 100319475328460015131 No Department of Oral Medicine, Dental Research Center, Hamadan University of Medical Sciences, Hamadan, Iran Fatemeh Ahmadi Motemayel 100319475328460015132 100319475328460015132 No Department of Biochemistry and Nutrition, Research Center for Molecular Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Mina Jazaeri 100319475328460015133 100319475328460015133 No Department of Oral Medicine, Faculty of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran Javad Feradmal 100319475328460015134 100319475328460015134 No Department of Biostatistics and Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran Mahdiye Zarabadi 100319475328460015135 100319475328460015135 No Department of Oral Medicine, Hamadan University of Medical Sciences, Haman, Iran Mostafa Hoseyni 100319475328460015136 100319475328460015136 No School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Parviz Torkzaban ptorkzaban@gmail.com 100319475328460015137 100319475328460015137 Yes Department of Periodontology, Dental Research Center, Hamadan University of Medical Sciences, Hamadan, Iran