fa Salivary total antioxidant capacity and lipid peroxidation in patients with erosive oral lichen planus بیماری های دهان Oral Medicine پژوهشي Research <b> Background and aims.</b> Oral lichen planus is a common chronic inflammatory disease of the oral mucosa with malignant potential, pathogenesis of which is not still well known. Free radicals and reactive oxygen species can play an important role in the pathogenesis of oral lichen planus. The aim of this study was to investigate salivary oxidative stress and antioxidant systems in patients with oral lichen planus.<div>  <b>Materials and methods</b>. In this case-control study, 30 patients with oral lichen planus (case group) and 30 age- and gender-matched healthy subjects (control group), referring to Dental School of Babol University of Medical Sciences, were selected using simple sampling method. Unstimulated saliva of the two groups was collected. Salivary total antioxidant capacity (TAC) and lipid peroxidation products were investigated and compared, using ferric reducing antioxidant power (FRAP) and thiobarbituric acid reactive substance (TBARS) methods, respectively. Data were analyzed using Student’s t-test. <div><b>Results.</b> The mean and standard deviation of salivary TAC in patients with oral lichen planus (297.23 ± 149.72 μM) was significantly lower than that in the controls (791.43±183.95 μM P < 0.0001), and mean and standard deviation of salivary malondialdehyde (MDA) (0.49 ± 0.30 μM) was remarkably higher in oral lichen planus patients compared to the control group (0.15 ± 0.11 μM) (P < 0.0001). TAC was also reduced in both groups in line with an increase in the level of MDA (P < 0.0001, r = −0.48). </div><div><b>Conclusion</b>. The results of this study suggested that an increase in oxidative stress and an imbalance in antioxidant defense system in the saliva of oral lichen planus patients may be involved in the pathogenesis of oral lichen planus.</div><hr><p class="MsoNormal" style="text-align: left direction: ltr unicode-bidi: embed"><b>Source: </b>Journal of Dental Research, Dental Clinics, Dental Prospects </p> <p class="MsoNormal" style="text-align: left direction: ltr unicode-bidi: embed"><a href="http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/627" target="_blank"><font color="#0000ff">Full Text</font></a></p></div> antioxidant,lichen planus, lipid peroxidation, saliva 0 0 http://idai.ir/browse.php?a_code=A-10-32-3263&slc_lang=fa&sid=1 Atena Shirzad 100319475328460015019 100319475328460015019 No Department of Oral Medicine, Dental School, Babol University of Medical Sciences, Babol, Iran Mahdi Pouramir 100319475328460015020 100319475328460015020 No Department of Biochemistry, Babol University of Medical Sciences, Babol, Iran Marayam SeyedMajidi 100319475328460015021 100319475328460015021 No Dental Materials Research Center, Dental School, Babol University of Medical Sciences, Babol, Iran Niloofarv Jenabian 100319475328460015022 100319475328460015022 No Department of Periodontology, Dental School, Babol University of Medical Sciences, Babol, Iran Ali Bijani 100319475328460015023 100319475328460015023 No Babol University of Medical Sciences, Babol, Iran Mina Motalleb Nejad mmotallebnejad@yahoo.com 100319475328460015024 100319475328460015024 Yes Cellular and Molecular Biology Research Center, Dental School, Babol University of Medical Sciences, Babol, Iran