fa Evaluation of the effect of two systemic doses of HESA-A on prevention of induced tongue neoplasm in rats بیماری های دهان Oral Medicine پژوهشي Research <b> Background and aims</b>. The aim of the present study was to compare the inhibitory effects of two systemic doses of HESA-A on prevention of 4-NQO-induced tongue neoplasms in rats. This study evaluated weight and histopathological changes. <div><b>Materials and methods. </b>Forty-eight male Sprague Dawley rats were divided into four groups of A, B, C and D of each 12 rats. The rats in groups B to D received 30 ppm of 4-Nitroquinoline-1-oxide (4-NQO) in drinking water for 12 weeks. When feeding with 4-NQO was initiated, the rats in groups B and C received HESA-A at doses of 250 and 500 mg/kg, respectively, 3 times a week. Body weights were measured three times a week. At the end, the rats were euthanized and the tongue was removed. Histological evaluations for carcinogenesis were carried out under a light microscope. </div><div><b>Results</b>. The mean body weights of rats in groups B, C and D were significantly lower than that in group A (P < 0.05). There were no significant differences in weight changes between groups B, C and D. In the present study, after 12 weeks of treatment, Tongue specimens in groups B and C did not exhibit severe dysplastic changes however, concurrent hyperplasia, without atypia and mild-to-moderate dysplastic changes were detected. These changes were significantly less than those in group D, with significant differences between group D and groups A, B and C (P<0.001, P<0.01 and P<0.05, respectively). </div><div><b>Conclusion</b>. HESA-A has dose-dependent inhibitory effects on the development of neoplasms of the tongue.</div><hr><p class="MsoNormal" style="text-align: left direction: ltr unicode-bidi: embed"><b>Source: </b>Journal of Dental Research, Dental Clinics, Dental Prospects </p> <p class="MsoNormal" style="text-align: left direction: ltr unicode-bidi: embed"><a href="http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/920" target="_blank"><font color="#0000ff">Full Text</font></a></p> 4-nitroquinoline-1-oxide, HESA-A, rat, tongue neoplasm 0 0 http://idai.ir/browse.php?a_code=A-10-32-3252&slc_lang=fa&sid=1 Massoumeh Mehdipour 100319475328460014978 100319475328460014978 No Department of Oral Medicine, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran Ali Taghavi Zenouz 100319475328460014979 100319475328460014979 No Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran Mehran Mesgari Abbasi 100319475328460014980 100319475328460014980 No Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Daryoush Mohajeri 100319475328460014981 100319475328460014981 No Department of Pathobiology, Faculty of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran Hossein Damghani 100319475328460014982 100319475328460014982 No Department of Oral Pathology, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran Sanaz Helli dr.s.helli@gmail.com 100319475328460014983 100319475328460014983 Yes Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Bita Abdollahi 100319475328460014984 100319475328460014984 No MSc Histology and Embryology, Drug Applied Research Center, Tabriz, Iran