fa Serum level of interleukin 17 in patients with erosive and non erosive oral lichen planus بیماری های دهان Oral Medicine پژوهشي Research <b> Background and aims. </b>Oral lichen planus is a relatively common chronic oral mucosal disease of unknown etiology. Regarding numerous studies on the immunologic factors involved in the etiology of lichen planus, the present study evaluated the serum interleukin-17 (IL-17) level in patients with erosive and non-erosive oral lichen planus.<div><b> Materials and methods.</b> This descriptive analytical study included 24 patients with erosive oral lichen planus (EOLP), 24 patients with non-erosive oral lichen planus (NEOLP) and 24 healthy volunteered as control. Blood samples of the subjects underwent ELISA, using special kits, to determine serum interleukin-17 levels. Data was analyzed using with descriptive statistic, chi-square test, and one-way ANOVA and Tukey post-hoc test with SPSS 16 software. </div><div><b>Results.</b> EOLP patients showed a high level of serum IL-17 compared with NEOLP patents and control groups (EOLP=184.16 ± 12.41 pg/mL, NEOLP=106.09±10.78 pg/mL, control=15.50 ± 4.34 pg/mL, P - 0.001). </div><div><b>Conclusion.</b> High level of serum IL-17 in erosive oral lichen planus patients compared to the non-erosive type and healthy individuals may be the reason for higher inflammation and atrophy in the erosive type.</div><hr><p class="MsoNormal" style="text-align: left direction: ltr unicode-bidi: embed"><b>Source: </b>Journal of Dental Research, Dental Clinics, Dental Prospects </p> <p class="MsoNormal" style="text-align: left direction: ltr unicode-bidi: embed"><a href="http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/432" target="_blank"><font color="#0000ff">Full Text</font></a></p> Oral Lichen Planus, Interleukin-17 0 0 http://idai.ir/browse.php?a_code=A-10-32-3229&slc_lang=fa&sid=1 Firooz Poualibaba 100319475328460014882 100319475328460014882 No Dntal and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran/Department of Oral Medicine, Faculty of Dentistry, Tabriz University, Tabriz, Iran Zohre Babaloo 100319475328460014883 100319475328460014883 No Department of Immunology, Faculty of Dentistry, Tabriz University, Tabriz, Iran Farzane Pakdel dr.farzaneh_ pakdel@yahoo.com 100319475328460014884 100319475328460014884 Yes Department of Oral Medicine, Faculty of Dentistry, Tabriz University, Tabriz, Iran Marziye Aghazadeh 100319475328460014885 100319475328460014885 No Department of Oral Medicine, Faculty of Dentistry, Tabriz University, Tabriz, Iran