en پاتولوزی دهان، فک و صورت Oral and Maxillofacial Pathology پژوهشي Research <div class="para"><p><b>Background: </b> Solid organ transplant patients are at an increased risk of developing lip malignancies. The role of HLA mismatch as a risk factor for such changes has only been described in skin.</p></div><div class="para"><p><b>Methods: </b> Lip lesions were evaluated in 403 solid organ transplant patients (immunosuppressed for at least 3 months) and findings compared to age and sex matched, otherwise healthy patients who acted as controls. HLA typing was provided for the transplant patients. All patients provided details of smoking history, alcohol consumption, skin type, as assessed by ease of burning to sunlight, and exposure to sunlight or other forms of ultraviolet radiation.</p></div><div class="para"><p><b>Results: </b> Lip lesions were identified in 36 transplant patients and 29 were biopsied. Fourteen of the biopsies confirmed dysplastic or malignant changes. For the control patients, one lesion was identified as dysplastic. The prevalence of dysplastic and malignant lip lesions was significantly higher (<em>P</em> = 0.006) in the transplant patients when compared to controls. Risk factors for dysplastic/malignant changes in the transplant group included age (<em>P</em> = 0.01), smoking (<em>P</em> = 0.033) and HLA-B mismatch (<em>P</em> = 0.001). Lip covering provided a significant reduction (<em>P</em> = 0.045) in the development of lip changes.</p></div><div class="para"><p><b>Conclusion: </b> All transplant patients should be regularly screened for lip malignancies and consulted on smoking and sunlight exposure. HLA-B mismatch does appear to make these patients more susceptible to dysplastic/malignant changes</p><p><hr></p><font size="3"><p dir="ltr"><strong>Source:</strong> Journal of Oral Pathology & Medicine</p><p dir="ltr"><a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0714.2011.01072.x/abstract" target="_blank"><font color="#0000cc">Full text</font></a></p></font></div> HLA typing,immunosuppression,lip malignancies,organ transplant 0 0 http://idai.ir/browse.php?a_code=A-10-32-300&slc_lang=en&sid=1 Anita Nolan 10031947532846001243 10031947532846001243 Yes Nick M. Girdler 10031947532846001244 10031947532846001244 No Robin A. Seymour 10031947532846001245 10031947532846001245 No J. Mark Thomason 10031947532846001246 10031947532846001246 No