fa Evaluation of Minichromosome Maintenance-3 (MCM3) in Oral Squamous Cell Carcinoma جراحی دهان، فک و صورت Oral and Maxillofacial Surgery پژوهشي Research <b> Statement of the Problem</b>: The expression of minichromosome maintenance-3 (MCM3) proteins and their diagnostic value in oral mucosal dysplasia and squamous cell carcinoma (SCC) is not well known. <div>  <b>Purpose:</b> This study was conducted to evaluate the usefulness of minichromosome maintenance 3 (MCM3) as a biomarker for diagnosis of oral premalignant lesions and SCC. </div><div>  <b>Materials and Method</b>: In this study, 31 oral SCC, 20 dysplastic epithelium and 20 controls were selected and immunohistochemical staining was done for MCM3. ANOVA, Tukey HSD, Mann-Whitney and Kruskal-Wallis tests were used to compare the groups and the correlation between different grades.</div><div><b> Results:</b> There was increasing trend of MCM3 from control to dysplastic epithelium and from dysplastic epithelium to SCC both in suprabasal layers and in total epithelial layers. MCM3 expression was elevated with increasing the grade of dysplasia, but there was no statistically significant difference (p= 0.93). The expression was also increased in high grades of SCC compared to lower grades. </div><div>  <b>Conclusion</b>: MCM3 can be used as a useful biomarker in the diagnosis of premalignant lesions and oral SCC.</div><hr><p class="MsoNormal" style="text-align: left direction: ltr unicode-bidi: embed"><b>Source: </b>Journal of Dentistry Shiraz University of Medical Sciences </p> <p class="MsoNormal" style="text-align: left direction: ltr unicode-bidi: embed"><a href="http://dentjods.sums.ac.ir/index.php/JDSUMS/article/view/594" target="_blank"><font color="#0000ff">Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-3122&slc_lang=fa&sid=1 Gita Rezvani 100319475328460014419 100319475328460014419 No Dept. of Oral & Maxillofacial Pathology, Dental School of Shahed University, Tehran, Iran Azadeh Andishe-Tadbir 100319475328460014420 100319475328460014420 No Dept. of Oral & Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran Mohammad Javad Ashraf 100319475328460014421 100319475328460014421 No Dept. of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Sara Amanpour 100319475328460014422 100319475328460014422 No Dept. of Oral & Maxillofacial Pathology, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran Fereshteh Kamali 100319475328460014423 100319475328460014423 No Dept. of Oral & Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. Sorena Fardisi sorenafardisi@gmail.com 100319475328460014424 100319475328460014424 Yes Dept. of Oral & Maxillofacial Surgery, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.