fa An Immunohistochemical Survey to Evaluate the Expression of CD105 and CD34 in Ameloblastoma and Odontogenic Keratocyst پاتولوزی دهان، فک و صورت Oral and Maxillofacial Pathology پژوهشي Research <b> Statement of the Problem:</b> Ameloblastoma is the most common odontogenic tumor which is slow-growing, locally invasive and exhibit specific biologic behavior and high recurrence rate. Likewise, odontogenic keratocyst is a developmental odontogenic cyst that has a high recurrence rate and aggressive behavior. There are limited studies considering the relationship between the angiogenesis factors and the biologic behavior of these lesions.<div><b> Purpose:</b> the aim of this study was to evaluate the mean density of vessels in odontogenic keratocysts and ameloblastoma and investigate its possible relationship with biological behavior of these lesions. </div><div>  <b>Materials and Method:</b> In this descriptive-analytic cross-sectional study, 40 cases, comprising 10 odontogenic keratocysts and 30 ameloblastomas (10 plexiform, 10 follicular, and 10 unicystic type) were selected and were stained immuno-histochemically with CD34 and CD105. The micro vessel density was assessed and compared in all groups. T- test for the independent samples’ One- way Anova, Wilcoxon test and Tukey tests were adopted for statistical analysis. </div><div>  <b>Results</b>: A statistically significant difference was observed in mean vascular density (MVD) between the odontogenic keratocyst and ameloblastoma groups concerning the CD105 and CD34 markers (p= 0.005, p= 0.000, respectively). The MVD was significantly higher in ameloblastomas than odontogenic keratocyst. MVD with CD34 was significantly higher than MVD with CD105 in ameloblastomas (p= 0.00).</div><div>  <b>Conclusion:</b> It can be suggested that angiogenesis might be one of the mechanisms that is more possible to contribute the aggressive biological behaviors in ameloblastoma rather than odontogenic keratocyst.</div><hr><p class="MsoNormal" style="text-align: left direction: ltr unicode-bidi: embed"><b>Source: </b>Journal of Dentistry Shiraz University of Medical Sciences </p> <p class="MsoNormal" style="text-align: left direction: ltr unicode-bidi: embed"><a href="http://dentjods.sums.ac.ir/index.php/JDSUMS/article/view/873" target="_blank"><font color="#0000ff">Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-3095&slc_lang=fa&sid=1 Shokoofeh Jamshidi 100319475328460014309 100319475328460014309 No Dental Research Center, Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran Massoumeh Zargaran 100319475328460014310 100319475328460014310 No Dental Research Center, Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran Fahime BAghaei 100319475328460014311 100319475328460014311 No Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran. Setare Shojaei s_shojaei_umsha@yahoo.com 100319475328460014312 100319475328460014312 Yes Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran. Reza Zare Mahmoodabadi 100319475328460014313 100319475328460014313 No Dental Research Center, Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran. Arash Dehghan 100319475328460014314 100319475328460014314 No Dept. of Pathology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. Abbas Moghimbeigi 100319475328460014315 100319475328460014315 No Modeling of Noncommunicable Disease Research Center, Dept. of Biostatistics and Epidemiology, School of Public Health, Ham- adan University of Medical sciences, Hamadan, Iran