fa Loading of Gentamicin Sulfate into Poly (Lactic-Co-Glycolic Acid) Biodegradable Microspheres ترمیمی Cosmetic and Restorative Dentistry پژوهشي Research <p style="background-color: rgb(239, 243, 250)"><strong style="margin: 0px padding: 0px border: 0px"><i style="margin: 0px padding: 0px border: 0px"> Objective: </i></strong>In dental treatments, use of carriers for targeted antibiotic delivery would be optimal to efficiently decrease microbial count. In this study, gentamicin was loaded into polylactic co-glycolic acid (PLGA) microspheres and its release pattern was evaluated for 20 days.</p><p style="background-color: rgb(239, 243, 250)"> <strong style="margin: 0px padding: 0px border: 0px"><i style="margin: 0px padding: 0px border: 0px"> Methods: </i></strong>In this experimental study, PLGA microspheres loaded with gentamycin were produced by the W/O/W method. The correct morphology of loaded microspheres was ensured using scanning electron microscopy (SEM). The rate of drug release from polymeric microspheres into the phosphate buffered saline (PBS) solution was measured during a 20-day period using spectroscopy. Data were analyzed using one-way ANOVA.</p><p style="background-color: rgb(239, 243, 250)"> <strong style="margin: 0px padding: 0px border: 0px"><i style="margin: 0px padding: 0px border: 0px"> Results: </i></strong>SEM micrographs showed that the produced microspheres had smooth and nonporous surfaces and 30-micron diameter. Assessment of the pattern of drug release from the PLGA microspheres loaded with gentamycin revealed a burst release on day six followed by a stable pattern of release until day 20.</p><p style="background-color: rgb(239, 243, 250)"> <strong style="margin: 0px padding: 0px border: 0px"><i style="margin: 0px padding: 0px border: 0px"> Conclusion: </i></strong>Considering the biocompatibility of PLGA and optimal pattern of drug release, PLGA microspheres loaded with gentamicin can be successfully used for infection control and reduction of microbial count in dental treatments.</p><hr><p class="MsoNormal" style="text-align: left direction: ltr unicode-bidi: embed"><b>Source: </b>Journal of Dental School Shahid Beheshti University of Medical Sciences </p> <p class="MsoNormal" style="text-align: left direction: ltr unicode-bidi: embed"><a href="http://jds.sbmu.ac.ir/browse.php?a_id=1408&sid=1&slc_lang=en" target="_blank"><font color="#0000ff">Full Text</font></a></p> Antibiotic, Controlled release, Drug release system, Gentamicin, Polylactic co-glycolic acid, Polymer microspheres., 0 0 http://idai.ir/browse.php?a_code=A-10-32-2957&slc_lang=fa&sid=1 Hanie Nojehdehian 100319475328460013747 100319475328460013747 No Dept. of Dental Materials, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran Malihe Ekrami 100319475328460013748 100319475328460013748 No Dept. of Operative Dentistry, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran Zahra Jaberi Ansari zahrajaberiansari@yahoo.com 100319475328460013749 100319475328460013749 Yes Dept. of restorative Dentistry, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran