en ترمیمی Cosmetic and Restorative Dentistry پژوهشي Research Objectives <p> To evaluate the effects of silica (SiO ₂ ) (0.5<img alt="AWT IMAGE" src="webfiles/images/transparent.gif" width="4" height="1" >wt%) and zinc oxide (ZnO) (0.25<img alt="AWT IMAGE" src="webfiles/images/transparent.gif" width="4" height="1" >wt%) dopants on the mechanical and biological properties of tricalcium phosphate (TCP) scaffolds with three dimensionally (3D) interconnected pores.</p>Methods <p> Scaffolds were created with a commercial 3D printer. Post sintering phase analysis was determined by X-ray diffraction. Surface morphology of the scaffolds was examined by field emission scanning electron microscopy (FESEM). Mechanical strength was evaluated with a screw driven universal testing machine. MTT assay was used for cellular proliferation characteristics and cellular morphology was examined by FESEM.</p>Results <p> Addition of dopants into TCP increased the average density of pure TCP from 90.8<img alt="AWT IMAGE" src="webfiles/images/transparent.gif" width="4" height="1" >±<img alt="AWT IMAGE" src="webfiles/images/transparent.gif" width="4" height="1" >0.8% to 94.1<img alt="AWT IMAGE" src="webfiles/images/transparent.gif" width="4" height="1" >±<img alt="AWT IMAGE" src="webfiles/images/transparent.gif" width="4" height="1" >1.6% and retarded the β to α phase transformation at high sintering temperatures, which resulted in up to 2.5 fold increase in compressive strength. <i>In vitro</i> cell–materials interaction studies, carried out using hFOB cells, confirmed that the addition of SiO ₂ and ZnO to the scaffolds facilitated faster cell proliferation when compared to pure TCP scaffolds.</p>Significance <p> Addition of SiO ₂ and ZnO dopants to the TCP scaffolds showed increased mechanical strength as well as increased cellular proliferation.</p><hr><p></p><p> <strong> Source: </strong>Dental Materials</p><p><a href="http://www.demajournal.com/article/S0109-5641(11)00838-4/abstract" target="_blank"><font color="#0000cc">  Full text </font></a></p> β-Tricalcium phosphate, Porous scaffold, Three dimensional printing, Doped calcium phosphates, Bone tissue engineering 0 0 http://idai.ir/browse.php?a_code=A-10-32-247&slc_lang=en&sid=1 Gary A. Fielding 1003194753284600986 1003194753284600986 Yes School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164-2920, USA Amit Bandyopadhyay 1003194753284600987 1003194753284600987 No Susmita Bose 1003194753284600988 1003194753284600988 No