fa The Effect of Celecoxib on Orthodontic Tooth Movement and Root Resorption in Rat جراحی دهان، فک و صورت Oral and Maxillofacial Surgery پژوهشي Research <p> <strong>Objective:</strong></p><p>  Inhibition of prostaglandin (PGs) production leads to decrease in orthodontic tooth movement (OTM). It is not known whether inhibition of cyclooxygenase-1 (COX-1) or cyclooxygenase-2 (COX-2) is the key mechanism for this effect. In this study, the effect of celecoxib, a highly-selective COX-2 inhibitor, was investigated on OTM in rats. </p><p> <strong>Materials and Methods</strong>:</p><p>  Four groups of male rats (seven animals in each goup) were used in the study. A 5mm-long nickel-titanium closed-coil spring was ligated between the right maxillary incisor and the first molar of each rat to deliver an initial force of 60g. All four groups recieved orthodontic appliances, group 1 received no injections, group 2 received celecoxib injections (0.3 mg in 0.1 ml saline solution), group 3 recieved normal saline injections (0.1 ml saline solution), and group 4 recieved needle penetration without injecting any solution. The local injections were carried out every 3 days for 18 days. All injections were subperiosteal and given in the upper right first molar mucosa. The animals were sacrificed 21 days after appliance insertion and OTM was measured. </p><p> <strong>Results:</strong></p><p>  In the animals treated with celecoxib a statistically significant decrease in OTM was observed compared with the other groups. Histological findings revealed that osteoclast count was significantly lower in group 2 compared with the other groups (P<0.05). The amount of root resorption showed a slight, but nonsignificant decrease in group 3. </p><p> <strong>Conclusion:</strong> </p><p> This study suggests that celecoxib decreases OTM and osteoclast count. This might be the result of COX-2 enzyme inhibition and subsequent decrease in prostaglandin production. </p><hr><p></p><p> <strong>Source: </strong>Journal of Dentistry of Tehran University of Medical Science</p><p><a href="Objective: Inhibition of prostaglandin (PGs) production leads to decrease in orthodontic tooth movement (OTM). It is not known whether inhibition of cyclooxygenase-1 (COX-1) or cyclooxygenase-2 (COX-2) is the key mechanism for this effect. In this study, the effect of celecoxib, a highly-selective COX-2 inhibitor, was investigated on OTM in rats." target="_blank"><font color="#0000ff"> Full Text</font></a></p> Orthodontics; Tooth Movement; Celecoxib; Prostaglandins; Cyclooxygenase; Rats 0 0 http://idai.ir/browse.php?a_code=A-10-32-2637&slc_lang=fa&sid=1 Ahmad Sodagar 100319475328460012428 100319475328460012428 No Dental Research Center and Department of Orthodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Tahura Etezadi 100319475328460012429 100319475328460012429 No Department of Orthodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Pouria Motahhary 100319475328460012430 100319475328460012430 No Department of Oral Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Ahmad Reza Dehpour 100319475328460012431 100319475328460012431 No School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Hamed Vaziri 100319475328460012432 100319475328460012432 No Private Practice, Farmington CT, USA Arash Khojasteh arashkhojasteh@yahoo.com 100319475328460012433 100319475328460012433 Yes Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Director of Basic Science research, Den-tal Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran