fa A Randomized Controlled Trial of a 10 Percent CPP-ACP Cream to Reduce Mutans Streptococci Colonization کودکان Pediatric Dentistry پژوهشي Research <p> <strong>Purpose:</strong></p><p>  The purpose of this study was to investigate the effectiveness of a 10 percent casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) cream to reduce mutans streptococci (MS) colonization and prevent early childhood caries. </p><p> <strong>Methods:</strong> </p><p> The cohort was randomized at mean age of 11 days old to receive once-daily CPP-ACP cream (n=102) or no product (comparison group n=89) from the time of first tooth eruption. All mothers were contacted by telephone at six, 12, and 18 months and advised to brush their children's teeth twice daily with low-dose fluoride toothpaste. At 24 months, all children were examined at a community clinic. </p><p> <strong>Results:</strong></p><p>  At 24 months old, one out of 65 (2 percent) children in the CPP-ACP group had caries vs. four out of 58 (seven percent) in the comparison group (difference not statistically significant). There were fewer MS-positive children in the CPP-ACP group (26 percent) vs. the comparison group (47 percent P=.02). A dose-response effect of CPP-ACP usage on MS was observed, where MS was present in eight percent of regular CPP-ACP users, 28 percent of irregular users, and 47 percent of non-users (P<.02).</p><p> <strong> Conclusions</strong>: </p><p> CPP-ACP reduced the percentages of mutans streptococci-positive 24-month-old children, although it did not reduce caries prevalence. </p><hr><p></p><p> <strong>Source: </strong>Journal of American Academy of ‍ Pediatric Dentistry</p><p> <a href="http://www.ingentaconnect.com/content/aapd/pd/2013/00000035/00000007/art00018" target="_blank"><font color="#0000ff">Full Text</font></a></p> CASEIN PHOSPHOPEPTIDE-AMORPHOUS CALCIUM PHOSPHATE; EARLY CHILDHOOD CARIES; MUTANS STREPTOCOCCI 0 0 http://idai.ir/browse.php?a_code=A-10-32-2611&slc_lang=fa&sid=1 Margaret L. Pukallus 100319475328460012327 100319475328460012327 No Senior oral health therapists, Metro South Health Service District, Queensland Health, Brisbane, Queensland, Australia Kathryn A. Plonka 100319475328460012328 100319475328460012328 No Senior oral health therapists, Metro South Health Service District, Queensland Health, Brisbane, Queensland, Australia Trevor F. Holcombe 100319475328460012329 100319475328460012329 No Director, Oral Health Program (Logan-Beaudesert Division), Metro South Health Service District, Queensland Health, Brisbane, Queensland, Australia Adrian G. Barnett 100319475328460012330 100319475328460012330 No Biostatistician, School of Public Health and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane Laurence J. Walsh 100319475328460012331 100319475328460012331 No Professor and director, Center for Pediatric Dentistry, The University of Queensland, Brisbane, Australia W. Kim Seow k.seow@uq.edu.au 100319475328460012332 100319475328460012332 Yes Head, School of Dentistry, The University of Queensland, Brisbane, Australia