fa Salivary peptide profile and its association with early childhood caries کودکان Pediatric Dentistry پژوهشي Research <p> <strong>Background</strong></p><p>  As dietary management during early childhood is a great barrier in caries control, there is a need for the identification of intrinsic risk factors, capable of allowing the use of a more cost-effective approach to early childhood caries (ECC). </p><p> <strong>Objective</strong></p><p> <strong> </strong>To evaluate the salivary peptide profile of children with and without ECC and its association with caries experience. </p><p> <strong>Methods</strong></p><p>  One hundred and six 10- to 71-month-old children participated in the study. Caries experience was determined through the visual/tactile method, based on the number of decayed, missing, and filled teeth, and surface scores (dmft/dmfs). Whole saliva was collected for mutans streptococci (MS) detection and peptide analysis. </p><p> <strong>Results</strong> </p><p> Chromatograms from CF (children without caries experience, n = 58) and CE (children with caries experience, n = 48) saliva pools expressed different patterns. Identification of molecular masses suggested the presence of nine peptides. Three of them were significantly related with caries experience. HNP-3 (α-defensin 3) (P = 0.019) and HBD-3 (β-defensin 3) (P = 0.034) reduced the chances of experiencing ECC. Proline-rich peptides IB-4 significantly increased caries experience (P = 0.035). Age (P = 0.020) and MS counts (P = 0.036) increased caries experience however, gender was not associated with dental caries (P = 0.877).<strong> </strong></p><p> <strong>Conclusion</strong> </p><p> Specific salivary peptides of CF or CE children in early childhood predispose to a higher or lower risk of caries experience. </p><hr><p></p><p> <strong>Source: </strong>International Journal of ‍ Pediatric Dentistry</p><p> <a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1365-263X.2012.01258.x/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-2479&slc_lang=fa&sid=1 Thyciana Rodrigues Ribeiro 100319475328460011814 100319475328460011814 No Department of Clinical Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil Karl J. Dria 100319475328460011815 100319475328460011815 No Department of Chemistry and Chemical Biology, Indiana University, Indianapolis, IN, USA Cibele Barreto Mano de Carvalho 100319475328460011816 100319475328460011816 No Department of Pathology and Legal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil André Jalles Monteiro 100319475328460011817 100319475328460011817 No Department of Statistics and Applied Mathematics, Federal University of Ceará, Fortaleza, Ceará, Brazil Manassés Claudino Fonteles 100319475328460011818 100319475328460011818 No Laboratory of Metabolic Pharmacology and Cellular Physiology, Federal University of Ceará, Fortaleza, Ceará, Brazil Krishnamurti de Moraes Carvalho 100319475328460011819 100319475328460011819 No Department of Physiologic Sciences, School of Medicine, State University of Ceará, Fortaleza, Ceará, Brazil Cristiane Sá Roriz Fonteles cfontele@ufc.br 100319475328460011820 100319475328460011820 Yes Department of Clinical Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil