fa Volumetric staging in oropharyngeal cancer patients treated with definitive IMRT بیماری های دهان Oral Medicine پژوهشي Research <p> <strong>Background</strong></p><p>  The superiority of volumetric staging (VS) over TNM/TNM-grouping system was previously prospectively tested in our head neck cancer population treated with intensity-modulated radiotherapy (IMRT) gross tumor volume (GTV) was the strongest predictor for disease control. Aim of this work was to specifically assess the prognostic value of VS in oropharyngeal cancer (OC). </p><p> <strong>Patients</strong></p><p>  Between 04/2002 and 12/2011, 277 consecutive OC patients underwent definitive IMRT. Mean/median follow-up was 33/27months (3–113). Three volumetric cut-offs were used (resulting in 4 GTV subgroups: 1–15cc (14%), 16–70cc (62%), 71–130cc (20%), >130cc (4%)). <strong></strong></p><p> <strong>Methods</strong></p><p>  Outcome in the OC subgroup was prospectively assessed with VS and compared with that resulting from TNM and AJCC staging.</p><p> <strong> Results</strong></p><p>  Primary GTV was most reliably predicting local control (p<0.0001), all other outcome parameters were predicted best by the total GTV (p<0.0001).</p><p> <strong> Conclusion</strong></p><p>  This is -to our knowledge- the first volumetric staging system for OC, and was found to be most reliable in predicting outcome in OC patients treated with IMRT. </p><hr><p></p><p> <strong>Source: </strong>Journal of Oral Oncology</p><p><a href="http://www.oraloncology.com/article/S1368-8375(12)00317-X/abstract" target="_blank"><font color="#0000ff"> Full Text</font></a></p> Volumetric staging, Tumor volume and outcome, Volumetric and cut off values, Oropharyngeal cancer, Mesopharyngeal cancer and SIB-IMRT 0 0 http://idai.ir/browse.php?a_code=A-10-32-2456&slc_lang=fa&sid=1 Gabriela Studer 100319475328460011697 100319475328460011697 Yes Department of Radiation Oncology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, CH, Switzerland Christoph Glanzmann 100319475328460011698 100319475328460011698 No