fa Total lesion glycolysis: A possible new prognostic parameter in oral cavity squamous cell carcinoma بیماری های دهان Oral Medicine پژوهشي Research <p> <strong>Objectives </strong></p><p> We sought to determine potential prognostic value of total lesion glycolysis (TLG) calculated from combined positron emission tomography/computed tomography (PET/CT) in patients with oral cavity squamous cell carcinoma (OSCC). </p><p> <strong>Materials and methods</strong></p><p>  We prospectively studied 126 patients with OSCC who underwent PET/CT before definitive treatment by radical surgery. The metabolic tumor volume (MTV) was calculated for the primary tumor according to an absolute standardized uptake value (SUV) of 3. TLG was calculated as MTV×the average SUV. The nodal SUVmax was also recorded. The median value of SUVmax and TLG were used to divide the patients into two categories (high and low). Patients were followed up until death or for at least 24months from their surgery. Disease-free (DFS) and disease-specific survivals (DSS) were the main outcome measures.</p><p> <strong> Results</strong></p><p>  The median TLG of the primary tumor (TTLG) was 71.4, and the median nodal SUVmax (NSUV) was 7.5. Patients with high TTLG (median) had a 2-year DFS of 52% whereas the DFS was 74% for those with a low TTLG (P=0.007) the 2-year-DSS rates were 53% vs. 84%, respectively (P<0.001). Similarly, patients with high NSUVmax (median) had a 2-year DFS of 42% vs. 70% for patients with a low NSUVmax (P=0.001) the 2-year-DSS rates were 39% vs. 78%, respectively (P<0.001). In multivariate analyses, TTLG, NSUVmax, and pathological nodal status were independent prognostic factors for the 2-year DSS. A 3-point prognostic scoring system was formulated based on the presence or absence of the independent factors. Patients with positive neck nodes, high NSUVmax, and high TTLG (score 3) had a 32-fold higher risk of cancer death compared with those lacking such risk factors (2-year-DSS=26% vs. 97%, P<0.001). </p><p> <strong>Conclusion</strong></p><p> <strong> </strong>Primary tumor TLG is an independent prognostic factor for cancer control and survival in patients with OSCC. A prognostic scoring system that includes primary tumor TLG, nodal SUVmax, and pathological neck status may be useful for risk stratification in this group of patients. </p><hr><p></p><p> <strong>Source: </strong>Journal of Oral Oncology</p><p><a href="http://www.oraloncology.com/article/S1368-8375(12)00292-8/abstract" target="_blank"><font color="#0000ff"> Full Text</font></a></p> Prognosis, Oral cancer, Tumor volume, Total lesion glycolysis, Squamous cell carcinoma, Positron emission tomography computed tomography, Fluorodeoxyglucose 0 0 http://idai.ir/browse.php?a_code=A-10-32-2455&slc_lang=fa&sid=1 Yasser G. Abd El-Hafez 100319475328460011692 100319475328460011692 Yes Radiotherapy and Nuclear Medicine Department, South Egypt Cancer Institute, Assiut University, Egypt Hosna M. Moustafa 100319475328460011693 100319475328460011693 No Department of Clinical Oncology and Nuclear Medicine, Kasr Aini Hospital, Cairo University, Egypt Haytham F. Khalil 100319475328460011694 100319475328460011694 No Department of Clinical Oncology and Nuclear Medicine, Kasr Aini Hospital, Cairo University, Egypt Chun-Ta Liao 100319475328460011695 100319475328460011695 No Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan Tzu-Chen Yen 100319475328460011696 100319475328460011696 No Nuclear Medicine Department and Molecular Imaging Center, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan