fa Dietary intervention for oral allergy syndrome as a treatment in orofacial granulomatosis: a new approach? بیماری های دهان Oral Medicine پژوهشي Research <p> <strong>Background </strong></p><p> Orofacial granulomatosis (OFG) is a chronic granulomatous condition of the mouth, face and lips. Recent work demonstrates a high rate of atopy and silver birch sensitisation from skin prick testing (SPT). Oral allergy syndrome (OAS) is an acute oro-pharyngeal IgE mediated reaction, triggered by foods that cross react with pollens, most commonly silver birch. The aim of this study was to determine if patients with OFG and positive SPT to common OAS associated pollens responded to avoidance of cross reactive foods. </p><p> <strong>Methods</strong> </p><p> Patients with OFG and positive SPT to silver birch, grass, mugwort, ragweed and latex were required to avoid cross reacting foods, for 6 weeks and, in those who responded, for a total of 12 weeks. All had standardized oral examinations and were given severity scores (SS) at each appointment. </p><p> <strong>Results</strong></p><p> <strong> </strong>Twenty two of 47 (47%) patients had one or more positive SPT and 13/22 completed 6 weeks on the diet. No difference was seen in SS between weeks 0 (14.62 ± 11.16) and 6 (13.31 ± 10.33 P = 0.656). Six of 14 (43%) had significantly improved SS (week 0 19.17 ± 12.95, week 6 10.83 ± 4.99, P = 0.027). Five completed 12 weeks and no further improvement was seen (week 6 11 ± 5.57, week 12 10.4 ± 9.94 P = 0.068). Two patients required no further treatments. </p><p> <strong>Conclusions</strong></p><p>  On an intention to treat basis, only 2/14 patients improved and required no further intervention. Whilst this diet cannot be recommended routinely, the improvement seen in some patients raises questions about the role of OAS in patients with OFG. </p><hr><p></p><p> <strong>Source: </strong>Journal of Oral Pathology & Medicine</p><p> <a href="http://onlinelibrary.wiley.com/doi/10.1111/jop.12041/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> oral allergy syndrome;orofacial granulomatosis 0 0 http://idai.ir/browse.php?a_code=A-10-32-2282&slc_lang=fa&sid=1 H. Campbell helen.1.campbell@kcl.ac.uk 100319475328460010816 100319475328460010816 Yes Diabetes and Nutritional Sciences Division, King's College London (KCL), London, UK/Department of Nutrition and Dietetics, Guy's and St Thomas' NHS Foundation Trust (GSTFT), London, UK/National Institute for Health Research (NIHR) Comprehensive Biomedical Research Centre at GSTFT and KCL, London, UK M.P. Escudier 100319475328460010817 100319475328460010817 No King's College London Dental Institute, London, UK J. Brostoff 100319475328460010818 100319475328460010818 No Diabetes and Nutritional Sciences Division, King's College London (KCL), London, UK P. Patel 100319475328460010819 100319475328460010819 No Department of Gastroenterology, GSTFT, London, UK P. Milligan 100319475328460010820 100319475328460010820 No Diabetes and Nutritional Sciences Division, King's College London (KCL), London, UK S.J. Challacombe 100319475328460010821 100319475328460010821 No King's College London Dental Institute, London, UK J.D. Sanderson 100319475328460010822 100319475328460010822 No Diabetes and Nutritional Sciences Division, King's College London (KCL), London, UK/Department of Gastroenterology, GSTFT, London, UK M.C.E. Lomer 100319475328460010823 100319475328460010823 No Diabetes and Nutritional Sciences Division, King's College London (KCL), London, UK/Department of Nutrition and Dietetics, Guy's and St Thomas' NHS Foundation Trust (GSTFT), London, UK/Department of Gastroenterology, GSTFT, London, UK