fa Wegener's granulomatosis: a review of clinical features and an update in diagnosis and treatment بیماری های دهان Oral Medicine پژوهشي Research Wegener's granulomatosis (WG) is an idiopathic, systemic inflammatory disease characterized by necrotizing granulomatous inflammation and pauci-immune small-vessel vasculitis of upper and lower respiratory tract and kidneys. The condition affects both genders equally, although some inconsistent gender differences have been observed. The aetiology of WG remains unknown although a number of exogenous factors have been suggested to be of aetiological relevance. Most clinical characteristics of this disease are non-specific, making clinical diagnosis challenging. Histopathological examination of lesional and peritoneal tissue is not pathognomonic, but is an essential investigation to confirm the presence of disease and exclude other disorders. At present, despite the increasingly wide range of potential therapies, cyclophosphamide plus corticosteroids remain the most recognized and effective means of inducing and sustaining remission of WG. <hr><p> <strong>Source: </strong>Journal of Oral Pathology & Medicine</p><p> <a href="http://onlinelibrary.wiley.com/doi/10.1111/jop.12030/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> Wegener\'s granulomatosis;granulomatous disease;oral disease 0 0 http://idai.ir/browse.php?a_code=A-10-32-2281&slc_lang=fa&sid=1 Hanan A. Almouhawis 100319475328460010812 100319475328460010812 No Oral Medicine unit, Department of Maxillofacial Medicine and Surgery, UCL Eastman Dental Institute, London, UK Jair C. Leao 100319475328460010813 100319475328460010813 No Oral Medicine unit, Department of Maxillofacial Medicine and Surgery, UCL Eastman Dental Institute, London, UK/Departamento de Clinica e Odontologia Preventiva, Universidade Federal de Pernambuco, Recife, Brazil Stefano Fedele 100319475328460010814 100319475328460010814 No Oral Medicine unit, Department of Maxillofacial Medicine and Surgery, UCL Eastman Dental Institute, London, UK Stephen R. Porter s.porter@ucl.ac.uk 100319475328460010815 100319475328460010815 Yes Oral Medicine unit, Department of Maxillofacial Medicine and Surgery, UCL Eastman Dental Institute, London, UK