fa CD1a-positive Langerhans cells and their relationship with E-cadherin in ameloblastomas and keratocystic odontogenic tumors پاتولوزی دهان، فک و صورت Oral and Maxillofacial Pathology پژوهشي Research <p> <strong>Background </strong></p><p> Ameloblastomas and keratocystic odontogenic tumors (KOTs) are lesions that are characterized by locally invasive growth and cause extensive bone destruction. In addition, it is known that E-cadherin influences the adhesion of Langerhans cells (LCs) to keratinocytes. </p><p> <strong>Objective and Methods </strong></p><p> The aim of this study was to investigate, using immunohistochemistry, the distribution of CD1a-positive cells in ameloblastomas and KOTs and their relationship with E-cadherin, in comparison to calcifying cystic odontogenic tumor (CCOT).</p><p> <strong> Results</strong> </p><p> The CD1a-positive LCs were observed in 11 ameloblastomas and KOTs. All of the cases of CCOT showed CD1a-positive LCs and a significant difference was found when this tumor was compared with ameloblastomas (P < 0.05, Mann–Whitney test). A statistically significant difference was also noted when comparing CD1a-positive LCs between CCOTs and KOTs (P < 0.05, Mann–Whitney test). Lower expression of E-cadherin in ameloblastomas (AMs) in relation to KOTs and CCOTs (P < 0.05, Fisher test) was observed. There was no correlation between E-cadherin and CD1a-positive LCs between all odontogenic tumors that were studied (P > 0.05, Spearman test). </p><p> <strong>Conclusion</strong></p><p>  A quantitative difference of CD1a-positive cells between AMs and KOTs in comparison to CCOTs was observed. This permits to speculate that a depletion of CD1a-positive LCs might influence the local invasiveness of ameloblastomas and KOTs. Furthermore, it is suggested that E-cadherin mediates cell adhesion in these tumors. </p><hr><p></p><p> <strong>Source: </strong>Journal of Oral Pathology & Medicine</p><p><a href="http://onlinelibrary.wiley.com/doi/10.1111/jop.12033/abstract" target="_blank"><font color="#0000ff"> Full Text</font></a></p> dendritic cell;E-cadherin;Langerhans cell;odontogenic tumors 0 0 http://idai.ir/browse.php?a_code=A-10-32-2273&slc_lang=fa&sid=1 Leonardo Araújo Mello 100319475328460010767 100319475328460010767 No Laboratory of Oral Surgical Pathology, Department of Oral Pathology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil Andréia Leal Figueiredo 100319475328460010768 100319475328460010768 No Department of Dental Public Health, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil Eduardo Antônio Gonçalves Ramos 100319475328460010769 100319475328460010769 No Laboratory of Pathology and Biology Molecular, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil Clarissa Araújo Silva Gurgel 100319475328460010770 100319475328460010770 No Laboratory of Oral Surgical Pathology, Department of Oral Pathology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil Manoela Domingues Martins 100319475328460010771 100319475328460010771 No Departament of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil Claúdia Roberta Leite Vieira de Figueiredo 100319475328460010772 100319475328460010772 No Department of General Pathology, Federal University of Paraíba, João Pessoa, Paraíba, Brazil Patrícia Ramos Cury 100319475328460010773 100319475328460010773 No Department of Periodontics, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil Ricardo Luiz Cavalcanti de Albuquerque Júnior 100319475328460010774 100319475328460010774 No Laboratory of Morphology and Structural Biology, Aracaju, Sergipe, Bahia, Brazil Luciana Maria Pedreira Ramalho 100319475328460010775 100319475328460010775 No Department of Stomatology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil Jean Nunes dos Santos jeanunes@ufba.br 100319475328460010776 100319475328460010776 Yes Laboratory of Oral Surgical Pathology, Department of Oral Pathology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil