fa Evaluation of GLUT-1 in the granular cell tumour and congenital granular cell epulis جراحی دهان، فک و صورت Oral and Maxillofacial Surgery پژوهشي Research <p> <strong>Background</strong></p><p>  The glucose transporter type 1 (GLUT-1) protein is a useful marker for perineurial cells. Because of the possible neuroectodermal histogenesis of the granular cell tumour and congenital granular cell epulis, the aim of this study was to assess the immunoexpression of GLUT-1 protein in granular cell tumour and congenital granular cell epulis to aid in clarifying their histogenesis. </p><p> <strong>Methods</strong> </p><p> The protocol of this study was approved by the Committee of Bioethics in Research at Universidade Federal Minas Gerais. Six cases of granular cell tumour and three cases of congenital granular cell epulis were submitted to immunohistochemistry for GLUT-1 and S-100 using the streptavidin-biotin standard protocol. </p><p> <strong>Results</strong> </p><p> Five cases of granular cell tumour were located on the tongue and one case on the upper lip. All cases of congenital granular cell epulis were observed in the alveolar ridge of newborns. All lesions evaluated proved to be immunonegative for GLUT-1. S-100 was found to be positive in all granular cell tumours and negative in congenital granular cell epulis.</p><p> <strong> Conclusions</strong> Neither granular cell tumour nor congenital granular cell epulis is directly related to perineurial cells. </p><hr><p></p><p> <strong>Source: </strong>Journal of Oral Pathology & Medicine</p><p><a href="http://onlinelibrary.wiley.com/doi/10.1111/jop.12035/abstract" target="_blank"><font color="#0000ff"> Full Text</font></a></p> congenital epulis;GLUT-1 protein;granular cell tumour;immunohistochemistry 0 0 http://idai.ir/browse.php?a_code=A-10-32-2272&slc_lang=fa&sid=1 Giovanna Ribeiro Souto grsouto@hotmail.com 100319475328460010761 100319475328460010761 Yes Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil Patrícia Carlos Caldeira 100319475328460010762 100319475328460010762 No Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil Aline Cristina Batista Rodrigues Johann 100319475328460010763 100319475328460010763 No School of Health and Biosciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil Helenicede Andrade Marigo 100319475328460010764 100319475328460010764 No Oral Pathology Laboratory, School of Dentistry, Pontifícia Universidade Católica de Minas Gerais, Belo Horizonte, Brazil Suzana Cantanhede Orsini Machadode Souza 100319475328460010765 100319475328460010765 No Department of Stomatology, School of Dentistry, Universidade de São Paulo, São Paulo, Brazil Ricardo Alves Mesquita 100319475328460010766 100319475328460010766 No Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil