fa HPV oral lesions in HIV-infected patients: the impact of long-term HAART بیماری های دهان Oral Medicine پژوهشي Research <p> <strong>Background</strong></p><p>  Since the introduction of highly active antiretroviral therapy (HAART), an increase in the frequency of human papillomavirus-associated oral lesions (HPV-OL) has been observed. Thus, the aim of this study was to determine the prevalence and factors associated with HPV-OL in Mexican HIV-infected patients, as well as its genotyping, in the HAART era. </p><p> <strong>Methods</strong></p><p>  In a cross-sectional study developed at an HIV/AIDS referral center in Mexico City, HIV-infected patients were consecutively included from 2004 to 2011. An oral exam was performed lymphocyte CD4+ count, HIV-viral load, CDC-stage, and HAART use were recorded. HPV-OL samples were taken for routine histopathological analysis (H-E) and HPV-DNA amplification/sequencing. Logistic regression models were performed and the interactions tested using the STATA software. </p><p> <strong>Results</strong> </p><p> Among 787 HIV patients, 55 (6.9%) showed HPV-OL. HPV-OLs were independently associated with age (≥40 years) and with a longer time of HAART use (≥12 months). The most frequent lesion was squamous cell papilloma in 22 (40%) cases, followed by multifocal epithelial hyperplasia in 15 (27.3%) cases. Labial mucosa was the most common site involved (56.4%). Of the sequences obtained, 65.4% corresponded to low risk and 11.5% to high risk. Mixed high- and low-risk infection were identified in 7.7% of the cases. </p><p> <strong>Conclusions</strong></p><p>  Human papillomavirus-associated oral lesions were associated with older age and longer HAART use. All lesions were benign in nature and most of the HPV sequences corresponded to low-risk types. The rise of HPV-OLs in HIV patients on HAART may be related with the longer life expectancy of individuals with an impaired immune system rather than a direct effect of HAART. </p><hr><p></p><p> <strong>Source: </strong>Journal of Oral Pathology & Medicine</p><p><a href="http://onlinelibrary.wiley.com/doi/10.1111/jop.12032/abstract" target="_blank"><font color="#0000ff"> Full Text</font></a></p> HAART ;human papillomavirus;oral warts 0 0 http://idai.ir/browse.php?a_code=A-10-32-2271&slc_lang=fa&sid=1 Gabriela Anaya-Saavedra 100319475328460010755 100319475328460010755 No Universidad Autónoma Metropolitana-Xochimilco, Ciudad de México, Mexico Bertha Flores-Moreno 100319475328460010756 100319475328460010756 No Universidad Autónoma Metropolitana-Xochimilco, Ciudad de México, Mexico Alejandro García-Carrancá 100319475328460010757 100319475328460010757 No Instituto Nacional de Cancerología (INCan), Ciudad de México, Mexico/Unidad de Virus y Cáncer, Instituto de Investigaciones Biomédicas, UNAM, Ciudad de México, Mexico Esther Irigoyen-Camacho 100319475328460010758 100319475328460010758 No Universidad Autónoma Metropolitana-Xochimilco, Ciudad de México, Mexico Miriam Guido-Jiménez 100319475328460010759 100319475328460010759 No Instituto Nacional de Cancerología (INCan), Ciudad de México, Mexico/Unidad de Virus y Cáncer, Instituto de Investigaciones Biomédicas, UNAM, Ciudad de México, Mexico Velia Ramírez-Amador rava1863@correo.xoc.uam.mx 100319475328460010760 100319475328460010760 Yes Universidad Autónoma Metropolitana-Xochimilco, Ciudad de México, Mexico