fa Epithelial and stromal syndecan-1 and -2 are distinctly expressed in oral- and cutaneous squamous cell carcinomas بیماری های دهان Oral Medicine پژوهشي Research <p> <strong>Background </strong></p><p> Oral squamous cell carcinoma (OSCC) and cutaneous squamous cell carcinoma (CSCC) are epithelial neoplasms of which OSCC has worse survival and higher risk of metastasis than CSCC. The aim of this study was to explore the differences of immunoexpressions between syndecan-1 and -2 in OSCC and head and neck CSCC.</p><p> <strong> Methods</strong></p><p>  A total of 35 patients diagnosed with OSCC and 25 with CSCC, presented T1 and T2 tumors and treated at Helsinki University Central Hospital between years 2001 and 2009, were selected into this study. The levels and locations of syndecan-1 and -2 immunostainings were analyzed using formalin-fixed and paraffin-embedded tissue samples of OSCC and CSCC cases together with clinical data. </p><p> <strong>Results</strong></p><p>  Cell membrane epithelial syndecan-1 expression decreased significantly compared to normal tissue in both cancer types. Cell membrane syndecan-1 expression in the invasive front had negative correlation with invasion depth of both tumors (OSCC, r = −0.339, P = 0.025 CSCC, r = −0.469, P = 0.004). In cancers over 4-mm invasion depth, the number of stromal syndecan-1-positive collagen fibers and inflammatory cells were higher in OSCC than in CSCC. Syndecan-2 expression in non-malignant stroma was higher in CSCC than in OSCC tumors. In addition, unlike syndecan-1, syndecan-2 was more often and more intensively expressed in the tumor inflammatory cells in CSCC than in OSCC. </p><p> <strong>Conclusion</strong></p><p>  Our results suggest that variable stromal expression of syndecan-1 and -2 in OSCC compared to CSCC may at least partially explain the differences in their clinical behavior. </p><hr><p></p><p> <strong>Source: </strong>Journal of Oral Pathology & Medicine</p><p><a href="http://onlinelibrary.wiley.com/doi/10.1111/jop.12025/abstract" target="_blank"><font color="#0000ff"> Full Text</font></a></p> oral cancer;syndecan 0 0 http://idai.ir/browse.php?a_code=A-10-32-2264&slc_lang=fa&sid=1 Abdirisak Ahmed Haji Omar abdirisak.ahmed@helsinki.fi 100319475328460010718 100319475328460010718 Yes Institute of Dentistry, University of Helsinki, Helsinki, Finland Caj Haglund 100319475328460010719 100319475328460010719 No Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland/Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland Susanna Virolainen 100319475328460010720 100319475328460010720 No Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland Valtteri Häyry 100319475328460010721 100319475328460010721 No Department of Otorhinolaryngology and Head and Neck Surgery, Helsinki University Central Hospital, Helsinki, Finland/University of Helsinki, Helsinki, Finland Timo Atula 100319475328460010722 100319475328460010722 No Department of Otorhinolaryngology and Head and Neck Surgery, Helsinki University Central Hospital, Helsinki, Finland Risto Kontio 100319475328460010723 100319475328460010723 No Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland Jarmo Rihtniemi 100319475328460010724 100319475328460010724 No Health Centre, City of Helsinki, Helsinki, Finland Antti Pihakari 100319475328460010725 100319475328460010725 No Health Centre, City of Helsinki, Helsinki, Finland Tuula Salo 100319475328460010726 100319475328460010726 No Department of Diagnostics and Oral Medicine, University of Oulu, Helsinki, Finland Jaana Hagström 100319475328460010727 100319475328460010727 No Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland/Department of Oral Pathology, Institute of Dentistry, University of Helsinki, Helsinki, Finland