fa Associations between single-nucleotide polymorphisms of the VEGF gene and long-term prognosis of oral squamous cell carcinoma جراحی دهان، فک و صورت Oral and Maxillofacial Surgery پژوهشي Research <p> <strong>Introduction </strong></p><p> Functional polymorphisms (SNPs) of the vascular endothelial growth factor (VEGF) are associated with the incidence of oral squamous cell carcinoma (OSCC). An impact of VEGF-SNPs on prognosis of OSCC patients seems possible. Therefore, correlations between prognostic parameters of OSCC patients and five VEGF-SNPs were determined.</p><p> <strong> Materials and Methods</strong> </p><p> In a retrospective long-term study, in 113 OSCC patients that underwent curative resections, five VEGF-SNPs (−1154 G/A, +405 G/C, +936 C/T, −2578 C/A, and −460 C/T) were analyzed. Associations between SNPs and prognosis (incidence of local recurrent disease, second cancer, metastases, death, total disease-free survival) were examined.</p><p> <strong> Results</strong> </p><p> After a mean follow-up time of 57.6 months, 32 patients had local recurrences 15 patients had second cancer, 15 patients metastases, and 23 patients died. The mean disease-free survival was 43.1 months. A significant increased incidence of OSCC in smokers with the VEGF −2578 A/C and −460 C/T SNP was seen (each P < 0.0001). In univariate analysis, patients with advanced OSCCs (T > 2 or N > 0) together with the −1154 A/A allele had a significant worse survival and a worse disease-free survival (both P < 0.04). The same was seen for the +405 G/G SNP (both P = 0.002). In multivariate analysis, only the negative influence of the +405 G/G SNP on survival in advanced OSCCs (T > 2) could be confirmed (P = 0.002). </p><p> <strong>Discussion</strong></p><p>  Possible reciprocal interactions between smoking and VEGF-SNP function were observed. Multivariate analysis confirmed the VEGF +405 G/G genotype to be associated with poor survival in advanced OSCCs a further use of this haplotype as biomarker has to be discussed. </p><hr><p></p><p> <strong>Source: </strong>Journal of Oral Pathology & Medicine</p><p><a href="http://onlinelibrary.wiley.com/doi/10.1111/jop.12026/abstract" target="_blank"><font color="#0000ff"> Full Text</font></a></p> advanced;long-term;oral squamous cell carcinoma;prognosis;single-nucleotide polymorphisms;smoking; VEGF 0 0 http://idai.ir/browse.php?a_code=A-10-32-2262&slc_lang=fa&sid=1 P.W. Kämmerer peer.kaemmerer@gmx.de 100319475328460010703 100319475328460010703 Yes Harvard Medical School, Boston, MA, USA/Department of Oral, Maxillofacial and Plastic Surgery, University Medical Centre, Mainz, Germany/M.R. Ambedkar Dental College and Hospital, Bangalore, India F.P. Koch 100319475328460010704 100319475328460010704 No Department of Oral, Maxillofacial and Plastic Surgery, University Medical Centre, Mainz, Germany E. Schiegnitz 100319475328460010705 100319475328460010705 No Department of Oral, Maxillofacial and Plastic Surgery, University Medical Centre, Mainz, Germany/M.R. Ambedkar Dental College and Hospital, Bangalore, India V.V. Kumar 100319475328460010706 100319475328460010706 No Department of Oral, Maxillofacial and Plastic Surgery, University Medical Centre, Mainz, Germany M. Berres 100319475328460010707 100319475328460010707 No Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Centre, Mainz, Germany T. Toyoshima 100319475328460010708 100319475328460010708 No Department of Oral and Maxillofacial Surgery, Kyushu University, Fukuoka, Japan B. Al-Nawas 100319475328460010709 100319475328460010709 No Department of Oral, Maxillofacial and Plastic Surgery, University Medical Centre, Mainz, Germany J. Brieger 100319475328460010710 100319475328460010710 No Department of Otorhinolaryngology, Johannes Gutenberg-University, Mainz, Germany