fa Correlation between salivary anti-HCV antibodies and HCV RNA in saliva and salivary glands of patients with chronic hepatitis C پاتولوزی دهان، فک و صورت Oral and Maxillofacial Pathology پژوهشي Research <p> <strong>Background</strong></p><p>  To investigate the correlation between anti-hepatitis C virus (HCV) antibodies in saliva and detection of HCV RNA in saliva and salivary glands of patients with chronic hepatitis C. </p><p> <strong>Methods</strong> </p><p> A total of 180 samples of saliva (131 non-stimulated and 49 stimulated) from 133 patients with chronic hepatitis C were tested by ELISA for presence of anti-HCV antibodies. Results were compared with the detection of HCV RNA in saliva and salivary glands samples. Pearson's chi-squared and Fisher's exact tests were performed for statistical analysis.</p><p> <strong> Results</strong></p><p>  Anti-HCV antibodies could be detected in 47/180 (26.1%) saliva samples. In 11/47 (23.5%) of these, HCV RNA was also detected. From the 133/180 (73.9%) saliva samples with undetectable anti-HCV antibodies, 49/133 (36.8%) were positive for HCV RNA at least in one saliva sample. From the 64 patients from whom salivary gland samples were available, 17/64 (26.6%) had detectable anti-HCV antibodies in saliva, from which 2/17 (11.8%) also had HCV RNA in the salivary gland. From the 47/64 (73.4%) cases negative for anti-HCV antibodies in saliva, 10/47 (21.3%) were positive for HCV RNA in salivary gland.</p><p> <strong> Conclusions</strong></p><p>  Taken together, our results suggest that there is no correlation between the presence of anti-HCV antibodies in saliva and the detection of HCV RNA in saliva and salivary glands in patients with chronic hepatitis C. Nevertheless, as there was a statistically significant difference between detection of anti-HCV antibodies and HCV RNA in stimulated saliva, our study points toward the need for new research on mechanisms of HCV shedding in saliva. </p><hr><p></p><p> <strong>Source: </strong>Journal of Oral Pathology & Medicine</p><p><a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0714.2012.01201.x/abstract" target="_blank"><font color="#0000ff"> Full Text</font></a></p> anti-HCV antibodies; HCV RNA ;hepatitis C virus;saliva;salivary glands 0 0 http://idai.ir/browse.php?a_code=A-10-32-2240&slc_lang=fa&sid=1 Patrícia Carlos Caldeira 100319475328460010570 100319475328460010570 No Department of Oral Pathology and Surgery, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil Karla Rachel Oliveira e Silva 100319475328460010571 100319475328460010571 No Department of Oral Pathology and Surgery, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil Tarcília Aparecida Silva 100319475328460010572 100319475328460010572 No Department of Oral Pathology and Surgery, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil Soraya de Mattos Camargo Grossmann 100319475328460010573 100319475328460010573 No School of Dentistry, Universidade Vale do Rio Verde, UNINCOR, Belo Horizonte, Brazil Rosângela Teixeira 100319475328460010574 100319475328460010574 No Department of Medical Clinic, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil Maria Auxiliadora Vieira do Carmo dorinhavc@gmail.com 100319475328460010575 100319475328460010575 Yes Department of Oral Pathology and Surgery, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil