fa Expression of oral secretory leukocyte protease inhibitor in HIV-infected subjects with long-term use of antiretroviral therapy پاتولوزی دهان، فک و صورت Oral and Maxillofacial Pathology پژوهشي Research <p> <strong>Background </strong></p><p> The objectives of this study were to determine (i) the expression of oral secretory leukocyte protease inhibitor (SLPI) in HIV-infected subjects compared with non-HIV controls, (ii) the oral SLPI expression in HIV-infected subjects with antiretroviral therapy (ART) compared with those without ART, and (iii) factors associated with the expression of oral SLPI. </p><p> <strong>Methods</strong> </p><p> Oral tissues and samples of both un-stimulated and stimulated saliva were collected from HIV-infected subjects with and without ART, and non-HIV individuals. The expression of SLPI mRNA in the tissue was determined by quantitative real-time PCR. Salivary SLPI protein was detected using ELISA. Chi-square test and logistic regression analysis were performed to determine the association between HIV/ART status and the expression of oral SLPI. </p><p> <strong>Results</strong></p><p>  One hundred and fifty-seven HIV-infected subjects were enrolled: 99 on ART (age range, 23–57 years mean, 39 years), 58 not on ART (age range, 20–59 years mean, 34 years), and 50 non-HIV controls (age range, 19–59 years mean, 36 years). The most common ART regimen was 2NRTIs + 1NNRTI. The expression of oral SLPI in stimulated saliva was significantly decreased with HIV infection (P < 0.001). The expression was also significantly different with respect to ART use (P = 0.007). Smoking, CD4+ cell count, and HIV viral load were the factors associated with the oral SLPI expression. </p><p> <strong>Conclusion</strong></p><p>  The expression of oral SLPI is altered by HIV infection and use of ART. Thus, oral SLPI may be the useful biomarker to identify subjects at risk of infections and malignant transformation due to HIV infection and long-term ART. </p><hr><p></p><p> <strong>Source: </strong>Journal of Oral Pathology & Medicine</p><p> <a href="http://onlinelibrary.wiley.com/doi/10.1111/jop.12023/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> ART ; HIV ;oral health;oral lesion;risk factor;secretory leukocyte protease inhibitor 0 0 http://idai.ir/browse.php?a_code=A-10-32-2238&slc_lang=fa&sid=1 Wipawee Nittayananta wipawee.ni@psu.ac.th 100319475328460010560 100319475328460010560 Yes Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand Marisa Kemapunmanus 100319475328460010561 100319475328460010561 No Department of Pathology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand Supaporn Yangngam 100319475328460010562 100319475328460010562 No Department of Biomedical Sciences, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand Sineepat Talungchit 100319475328460010563 100319475328460010563 No Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, Srinakharinwirot University, Bangkok, Thailand Hutcha Sriplung 100319475328460010564 100319475328460010564 No Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand