fa Allelic variants of XRCC1 and XRCC3 repair genes and susceptibility of oral cancer in Brazilian patients بیماری های دهان Oral Medicine پژوهشي Research <p> <strong>Background: </strong></p><p>  The capacity for DNA repair is essential in maintaining cellular functions and homeostasis however, this capacity can be altered based on DNA sequence variations in DNA repair genes, which may contribute to the onset of cancer. Many single-nucleotide polymorphisms (SNPs) in repair genes have been found to be associated with oral cancer. The aim of this study was to investigate the relationship between the presence of allelic variants Arg194Trp (rs:1799782) and Arg399Gln (rs: 25487) of XRCC1 gene and Thr241Met (rs: 861539) of XRCC3 gene and susceptibility to oral cancer. We also attempted to correlate the frequencies obtained for each of the SNPs to histopathological parameters. <strong></strong></p><p> <strong>Methods:</strong></p><p>   A case–control study was conducted with genomic DNA from 150 patients with oral squamous cell carcinomas and 150 controls. SNPs were genotyped by RFLP-PCR. </p><p> <strong>Results:</strong></p><p> <strong> </strong> The presence of the polymorphic variants of the XRCC1 gene within codon 194 (OR 0.82, 95% CI: 0.44–1.51) and codon 399 (OR 0.94, 95% CI: 0.59–1.50) and within the XRCC3 gene (OR 0.72 95% CI: 0.45–1.16) were not associated with an increased risk of oral cancer. A combinational analysis of SNPs in both genes indicated no association. The presence of the allelic variants of these two genes had no statistically significant effect on tumor differentiation, lymph node invasion or tumor size. </p><p> <strong>Conclusions:</strong></p><p>   These results suggest that allelic variants of XRCC1 and XRCC3 are not suitable markers for susceptibility to carcinomas of the oral cavity and are also not related to the later stages of such tumors. </p><hr><p></p><p> <strong>Source: </strong>Journal of Oral Pathology & Medicine</p><p><a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0714.2012.01192.x/abstract" target="_blank"><font color="#0000ff"> Full Text</font></a></p> histopathological parameters;oral cancer;polymorphisms; XRCC1 ; XRCC3 0 0 http://idai.ir/browse.php?a_code=A-10-32-2234&slc_lang=fa&sid=1 Mariana Bisarro dos Reis 100319475328460010540 100319475328460010540 No Departamento de Biologia Geral, Universidade Estadual de Londrina, Londrina, PR, Brazil Roberta Losi-Guembarovski 100319475328460010541 100319475328460010541 No Departamento de Biologia Geral, Universidade Estadual de Londrina, Londrina, PR, Brazil Enilze Maria de Souza Fonseca Ribeiro 100319475328460010542 100319475328460010542 No Departamento de Genética, Universidade Federal do Paraná, Curitiba, PR, Brazil Iglenir João Cavalli 100319475328460010543 100319475328460010543 No Departamento de Genética, Universidade Federal do Paraná, Curitiba, PR, Brazil Maria Celeste Morita 100319475328460010544 100319475328460010544 No Departamento de Medicina Oral e Odontologia Infantil, Universidade Estadual de Londrina, Londrina, PR, Brazil Gyl Henrique Albrecht Ramos 100319475328460010545 100319475328460010545 No Hospital Erasto Gaertner, Serviço de Cabeça e Pescoço, Curitiba, PR, Brazil Benedito Valdecir de Oliveira 100319475328460010546 100319475328460010546 No Hospital Erasto Gaertner, Serviço de Cabeça e Pescoço, Curitiba, PR, Brazil Lauro Toyoshi Mizuno 100319475328460010547 100319475328460010547 No Centro Odontológico Norte do Paraná, Universidade Estadual de Londrina, Londrina, PR, Brazil Silvia Regina Rogatto 100319475328460010548 100319475328460010548 No Departamento de Urologia, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista Júlio de Mesquita Filho, Botucatu, SP, Brazil Ilce Mara Syllos Cólus colus@sercomtel.com.br 100319475328460010549 100319475328460010549 Yes Departamento de Biologia Geral, Universidade Estadual de Londrina, Londrina, PR, Brazil