fa The role of specific cow's milk proteins in the etiology of recurrent aphthous ulcers بیماری های دهان Oral Medicine پژوهشي Research <p> <strong>Background </strong></p><p> Recurrent aphthous ulcerations (RAU), or recurrent aphthous stomatitis, is recognized as one of the most common oral mucosal diseases worldwide. It was noted some connection between immunity to cow's milk proteins (CMP) and oral diseases. The goal of this study was to determine the prevalence of the increased levels of serum antibodies to specific cow's milk proteins (SCMP), constituents of cheese or of whey, by enzyme-linked immunosorbent assay (ELISA) test, in subjects who have RAU. </p><p> <strong>Methods </strong></p><p> Fifty subjects with RAU and 50 healthy people, as controls (C), were included in this research. Levels of serum IgA, IgG, and IgE antibodies to SCMP were determined by ELISA. The statistical analysis of data was performed by Wilcoxon rank sum test with continuity correction. <strong></strong></p><p> <strong>Results</strong></p><p>  The levels of serum anti-SCMP IgA, IgG, and IgE antibodies were significantly higher in subjects with RAU in comparison with controls (P < 0.005). </p><p> <strong>Conclusions</strong></p><p>  These results indicate the strong association between high levels of serum anti-SCMP IgA, IgG, and IgE antibodies, especially to caseins: α-, β-, and κ-casein from cow's milk and clinical manifestations of RAU. Serum immunity to the whey proteins in subjects with RAU was not in so high percentage expressed. </p><hr><p></p><p> <strong>Source: </strong>Journal of Oral Pathology & Medicine</p><p> <a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0714.2012.01204.x/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> IgA;IgE;IgG;immunoreactivity;recurrent aphthous ulcers;specific cow\'s milk proteins 0 0 http://idai.ir/browse.php?a_code=A-10-32-2220&slc_lang=fa&sid=1 Irina Besu irina.besu@ncrc.ac.rs 100319475328460010459 100319475328460010459 Yes Institute of Oncology and Radiology of Serbia, Belgrade, Serbia Ljiljana Jankovic 100319475328460010460 100319475328460010460 No Clinic for Periodontology and Oral medicine, Faculty of Stomatology, University of Belgrade, Belgrade, Serbia Aleksandra Konic-Ristic 100319475328460010461 100319475328460010461 No Department of Nutrition and Metabolism, Institute for Medical Research, Belgrade, Serbia Sanvila Raskovic 100319475328460010462 100319475328460010462 No Institute of Allergology and Immunology, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia Valeri Besu 100319475328460010463 100319475328460010463 No Dental Ordination, Dr Besu, Zrenjanin, Serbia Milanko Djuric 100319475328460010464 100319475328460010464 No Clinic for Dentistry, School of Medicine, University of Novi Sad, Novi Sad, Serbia Sasa Cakic 100319475328460010465 100319475328460010465 No Clinic for Periodontology and Oral medicine, Faculty of Stomatology, University of Belgrade, Belgrade, Serbia Ileana Ursu Magdu 100319475328460010466 100319475328460010466 No Clinic for Periodontology and Oral medicine, Faculty of Stomatology, University of Belgrade, Belgrade, Serbia Zorica Juranic 100319475328460010467 100319475328460010467 No Institute of Oncology and Radiology of Serbia, Belgrade, Serbia