fa The role of carbonic anhydrase IX in hypoxia control in OSCC بیماری های دهان Oral Medicine پژوهشي Research Tumoral microenvironments play a key role in the evolution of solid tumors. Tumor hypoxia is actively involved in the promotion of genetic instability, the invasive capacity of tumor cells, metastasis, and a worsening of the clinical evolution. Endogenous hypoxia markers are controlled by hypoxia-related genes, formed by HIF-1, which is related to several target genes that involve the energy metabolism, angiogenesis, and transmembrane carbonic anhydrases (CAs), mainly CA-IX that is one of the tumor-related carbonic anhydrases. The goal of this paper is to establish the role of CA-IX as a hypoxia marker in OSCC, while analyzing its expression in this type of tumors and its relationship with several clinical and pathological parameters and prognosis, evaluating its relationship with angiogenesis, other hypoxia markers, and clarifying its role in chemotherapy and radiotherapy resistance. <hr><p> <strong>Source: </strong>Journal of Oral Pathology & Medicine</p><p> <a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0714.2012.01144.x/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> CA-IX;Carbonic anhydrases;Hypoxia;Oral squamous cell carcinoma 0 0 http://idai.ir/browse.php?a_code=A-10-32-2209&slc_lang=fa&sid=1 Mario Pérez-Sayáns perezsayans@gmail.com 100319475328460010403 100319475328460010403 Yes Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain Claudiu T. Supuran 100319475328460010404 100319475328460010404 No Laboratorio di Chimica Bioinorganica, Università degli Studi di Firenze, Sesto Fiorentino (Firenze), Italy Silvia Pastorekova 100319475328460010405 100319475328460010405 No nstitute of Virology, Slovak Academy of Sciences José Manuel Suárez-Peñaranda 100319475328460010406 100319475328460010406 No Servicio de Anatomia Patológica, Hospital Clinico Universitario de Santiago, Choupana s/n Santiago de Compostela, Spain Gayoso-Diz Pilar 100319475328460010407 100319475328460010407 No Clinical Epidemiology and Biostatistics Unit, Hospital Clínico Universitario de Santiago de Compostela, Spain Francisco Barros-Angueira 100319475328460010408 100319475328460010408 No Unidad de Medicina Molecular – Fundación Pública Galega de Medicina Xenómica, Edificio de Consultas planta, Hospital Clinico Universitario C.P. Santiago de Compostela, Spain José Manuel Gándara-Rey 100319475328460010409 100319475328460010409 No Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Entrerríos s/n, Santiago de Compostela, Spain Abel García-García 100319475328460010410 100319475328460010410 No Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain