fa Efficacy in reducing dentine hypersensitivity of a regimen using a toothpaste containing 8% arginine and calcium carbonate, a mouthwash containing 0.8% arginine, pyrophosphate and PVM/MA copolymer and a toothbrush compared to potassium and negative control regimens: An eight-week randomized clinical trial مقالات عمومي General پژوهشي Research <p> <strong>Objective</strong></p><p>  Evaluate the efficacy of three regimens integrating toothpaste, toothbrush and mouthwash in reducing dentine hypersensitivity. </p><p> <strong>Methods</strong></p><p>  Eight-week single-centre, three-cell, double-blind, randomized study was conducted in the Dominican Republic. Subjects entered one of the three regimens: (1) toothpaste containing 8% arginine and 1450ppm mono-fluorophosphate, in a calcium carbonate base, a soft-bristle toothbrush followed by a mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride (2) toothpaste containing 5% potassium nitrate and 1450ppm sodium fluoride, a soft-bristle toothbrush, followed by a mouthwash containing 0.51% potassium chloride and 230ppm sodium fluoride and (3) toothpaste containing 1450ppm mono-fluorophosphate, a soft-bristle toothbrush followed by a fluoride/arginine free mouthwash. Tactile and Air-Blast dentine hypersensitivity measurements were performed at baseline, two, four, and eight weeks. For treatment group comparisons, ANCOVA and post hoc Tukey's pair-wise (α=0.05) were used. Kaplan–Meier survival analysis was performed to evaluate Time to Treatment Improvement. </p><p> <strong>Results</strong> </p><p> 120 subjects were enrolled, 118 completed the study. The Tactile hypersensitivity mean scores showed statistically significant improvement at two, four and eight (p≤0.001) weeks in the arginine regime the potassium regime did not show significant (p≥0.05) improvement. Air-Blast Hypersensitivity scores had a statistically significant decrease at two (p=0.006), four (p=0.006) and eight (p=0.002) weeks in arginine and potassium regimes (p≤0.05). The most effective treatment proved to be arginine (p≤0.05) compared to the potassium regime. <strong></strong></p><p> <strong>Conclusion</strong> </p><p> Arginine regimen provided the greatest reduction in Tactile and Air-Blast dentine hypersensitivity compared to potassium and negative control regimens and provides faster dentine hypersensitivity relief than potassium regimen. </p><hr><p></p><p> <strong>Source: </strong>Journal of Dentistry</p><p><a href="http://www.jodjournal.com/article/S0300-5712(12)00313-2/abstract" target="_blank"><font color="#0000ff"> Full Text</font></a></p> Efficacy, Dentine, Hypersensitivity, Mouthwash, Tactile, Air-Blast 0 0 http://idai.ir/browse.php?a_code=A-10-32-2130&slc_lang=fa&sid=1 Augusto R. Elias Boneta 10031947532846009991 10031947532846009991 Yes University of Puerto Rico, School of Dental Medicine, San Juan, Puerto Rico, USA Karol Ramirez 10031947532846009992 10031947532846009992 No University of Puerto Rico, School of Dental Medicine, San Juan, Puerto Rico, USA Joselyn Naboa 10031947532846009993 10031947532846009993 No Calle Juan Bautista, Vicini #5, Condominio Delfin, Santo Domingo, Dominican Republic Luis R. Mateo 10031947532846009994 10031947532846009994 No LRM Statistical Consulting, Hoboken, NJ, USA Bernal Stewart 10031947532846009995 10031947532846009995 No Colgate-Palmolive Technology Center, Piscataway, NJ, USA Foti Panagokos 10031947532846009996 10031947532846009996 No Colgate-Palmolive Technology Center, Piscataway, NJ, USA William De Vizio 10031947532846009997 10031947532846009997 No Colgate-Palmolive Technology Center, Piscataway, NJ, USA