fa THE PROPHYLACTIC EFFECTS OF ZINTOMA AND IBUPROFEN ON POST-ENDODONTIC PAIN OF MOLARS WITH IRREVERSIBLE PULPITIS: A RANDOMIZED CLINICAL TRIAL اندودانتیکس Endodontics پژوهشي Research <p> <strong>Introduction:</strong></p><p>  Post endodontic pain is often linked to the inflammatory process as well as additional central mechanisms. The purpose of the present double-blind randomized clinical trial study was to compare the prophylactic effects of a derivative of Zingiber Officinale, Zintoma, and Ibuprofen on post endodontic pain of molars with irreversible pulpitis. </p><p> <strong>Materials and Methods:</strong></p><p>  The post endodontic pain of 72 enrolled patients suffering from irreversible pulpitis was assessed after prophylactic use of 400 mg Ibuprofen, 2 gr Zintoma and placebo. Using the Heft-Parker Visual Analogue Scale, the patients recorded their perceived pain before taking the medicament (baseline), immediately after and also at 4, 8, 12, 24, 48, and 72 h post one-visit endodontic treatment. The statistical analysis was done using Kruskal-Wallis, Mann-Whitney, and Freedman tests (P<0.05). </p><p> <strong>Results:</strong> </p><p> At all times, there was significant difference between the Ibuprofen and Zintoma (P<0.05) and also between the Ibuprofen and placebo (P<0.05). However, there was no significant difference between Zintoma and the placebo in any of time intervals (P>0.05). No side effects were observed. </p><p> <strong>Conclusion:</strong></p><p>  The obtained results of the trial revealed that prophylactic use of 2 gr Zintoma is not an effective pain relieving agent. </p><hr><p></p><p> <strong>Source: </strong>Iranian Endodontic Journal </p><p> <a href="http://journals.sbmu.ac.ir/index.php/iej/article/view/4080" target="_blank"><font color="#0000ff">Full Text</font></a></p> Analgesics; Anti-Inflammatory Agents; Ibuprofen; Non-Steroidal; Pain Measurement; Pulpitis; Visual Analogue Pain Scale; Zintoma 0 0 http://idai.ir/browse.php?a_code=A-10-32-2087&slc_lang=fa&sid=1 Mohsen Ramazani Ramazani77@zaums.ac.ir 10031947532846009776 10031947532846009776 Yes Department of Endodontics, Dental School, Mazandaran University of Medical Sciences, Sari, Iran Mahmoud Reza Hamidi 10031947532846009777 10031947532846009777 No Department of Endodontics, Dental School, Babol University of Medical Sciences, Babol, Iran Ali Akbar Moghaddamnia 10031947532846009778 10031947532846009778 No Department of Pharmacology and Toxicology, Medical School, Babol University of Medical Sciences, Babol, Iran Nahid Ramazani 10031947532846009779 10031947532846009779 No Department of Pedodontics, Children And Adolescent Health Research Center, Dental School, Zahedan University of Medical Sciences, Zahedan, Iran Nafiseh Zarenejad 10031947532846009780 10031947532846009780 No Department of Restorative Dentistry, Dental School, Babol University of Medical Sciences, Babol, Iran