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Literature & Humanities
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Biochemical markers of bone metabolism in gingival crevicular fluid during early orthodontic tooth movement
ارتودنسی
Orthodontics
پژوهشي
Research
<p> <strong>Objective:</strong></p><p> To evaluate the expression of an activator of nuclear factor-kappa (RANK), osteoprotegerin (OPG), osteopontin (OPN), and transforming growth factor ß1 (TGF-ß1) in gingival crevicular fluid (GCF) of teeth subjected to orthodontic forces. </p><p> <strong>Materials and Methods:</strong></p><p> A randomized, pilot clinical trial including 10 healthy volunteers was conducted using a split-mouth design. Orthodontic elastic separators were placed between the second premolar and first molar, with the contralateral quadrant serving as a control. The GCF samples were collected from the tension and compression sites at baseline, 24 hours, and 7 days after the placement of separators. The GCF sample volumes were measured using a Periotron 8000, and total protein concentrations were determined. Levels of RANK, OPG, OPN, and TGF-ß1 were also analyzed using a multiplex enzyme-linked immunosorbent assay. </p><p> <strong>Results:</strong></p><p> The control sites remained unchanged throughout the study. In contrast, the concentration of OPG significantly decreased at the compression site by 24 hours, and the amount and concentration of RANK differed significantly between the control, compression, and tension sites after 7 days. A significant increase in absolute TGF-ß1 levels was also detected at the compression site versus the control and tension sites after 7 days. </p><p> <strong>Conclusion</strong>:</p><p> Bone metabolism is affected by application of force to the teeth by elastic separators. Both increased expression of bone resorptive mediators (eg, RANK and TGF-ß1) and decreased expression of a bone-forming mediator (eg, OPG) on the compression side were detected. </p><hr><p></p><p> <strong>Source: </strong>The Angel Orthodontists</p><p> <a href="http://www.angle.org/doi/abs/10.2319/022812-168.1" target="_blank"><font color="#0000ff">Full Text</font></a></p>
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http://idai.ir/browse.php?a_code=A-10-32-1915&slc_lang=fa&sid=1
German
barbieri
10031947532846008963
10031947532846008963
No
Department of Periodontology, Faculty of Odontology, University Complutense, Madrid, Spain
Patricia
Solano
10031947532846008964
10031947532846008964
No
Department of Periodontology, Faculty of Odontology, University Complutense, Madrid, Spain
Jose Antonio
Alarcón
10031947532846008965
10031947532846008965
No
Department of Orthodontics, Faculty of Odontology, University of Granada
Ronaldo
Vernal
10031947532846008966
10031947532846008966
No
Periodontal Biology Laboratory, Faculty of Odontology, University of Chile, Santiago, Chile
Judith
Rios-Lugo
10031947532846008967
10031947532846008967
No
Department of Periodontology, Faculty of Odontology, University Complutense, Madrid, Spain
Mariano
Sanz
10031947532846008968
10031947532846008968
No
Department of Surgery and Oral Medicine, Faculty of Odontology, University Complutense, ETEP Research Group, Madrid, Spain
Conchita
Martín
conchitamartin@odon.ucm.es
10031947532846008969
10031947532846008969
Yes
Department of Orthodontics, Faculty of Odontology, University Complutense, ETEP Research Group, Madrid, Spain