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Occlusal hypofunction causes periodontal atrophy and VEGF/VEGFR inhibition in tooth movement
ارتودنسی
Orthodontics
پژوهشي
Research
<p> <strong>Objective:</strong></p><p> To examine changes in microvasculature and the expression of vascular endothelial growth factor A (VEGF-A) and VEGF receptor 2 (VEGFR-2) in rat hypofunctional periodontal ligament (PDL) during experimental tooth movement. </p><p> <strong>Materials and Methods</strong>: </p><p> Twelve-week-old male Sprague-Dawley rats were divided into normal occlusion and occlusal hypofunction groups. After a 2-week bite-raising period, rat first molar was moved mesially using a 10-gf titanium-nickel alloy closed coil spring in both groups. On days 0, 1, 2, 3, and 7 after tooth movement, histologic changes were examined by micro–computed tomography and immunohistochemistry using CD31, VEGF-A, VEGFR-2, and the terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) method.</p><p> <strong> Results</strong>:</p><p> Hypofunctional molars inclined more than normal molars and did not move notably after day 1 of tooth movement. Blood vessels increased on the tension side of the PDL in normal teeth. Immunoreactivities for VEGF-A and VEGFR-2 in normal teeth were greater than those in hypofunctional teeth during tooth movement. Compressive force rapidly caused apoptosis of the PDL and vascular endothelial cells in hypofunctional teeth, but not in normal teeth. </p><p> <strong>Conclusions</strong>:</p><p> Occlusal hypofunction induces vascular constriction through a decrease in the expression of VEGF-A and VEGFR-2, and apoptosis of the PDL and vascular cells occurs during tooth movement. </p><hr><p></p><p> <strong>Source: </strong>The Angel Orthodontists</p><p> <a href="http://www.angle.org/doi/abs/10.2319/011712-45.1" target="_blank"><font color="#0000ff">Full Text</font></a></p>
Occlusal hypofunction, Tooth movement, VEGF, VEGFR
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http://idai.ir/browse.php?a_code=A-10-32-1913&slc_lang=fa&sid=1
Risa
Usumi-Fujita
10031947532846008952
10031947532846008952
No
Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Jun
Hosomichi
hosomichi.orts@tmd.ac.jp
10031947532846008953
10031947532846008953
Yes
Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Noriaki
Ono
10031947532846008954
10031947532846008954
No
Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Naoki
Shibutani
10031947532846008955
10031947532846008955
No
Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Sawa
Kaneko
10031947532846008956
10031947532846008956
No
Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Ysuhiro
Shimizu
10031947532846008957
10031947532846008957
No
Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Takshi
Ono
10031947532846008958
10031947532846008958
No
Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan