fa Stabilization of tooth movement by administration of reveromycin A to osteoprotegerin-deficient knockout mice ارتودنسی Orthodontics پژوهشي Research <p> <strong>Introduction</strong></p><p>  In this study, mechanical stress in the form of tooth movement was applied to osteoprotegerin-deficient knockout mice, which served as an animal model for juvenile Paget’s disease. To compare and evaluate bone turnover and response of the surrounding bony tissue, we administered reveromycin A. We also investigated the ability of reveromycin A to control osteoclastic activity in juvenile Paget’s disease. <strong></strong></p><p> <strong>Methods</strong> </p><p> Eight-week-old male osteoprotegerin-deficient knockout and wild-type mice were injected with reveromycin A (15 mg/kg of body weight) intraperitoneally twice daily. An elastic module was inserted interproximally between the maxillary left first and second molars. </p><p> <strong>Results</strong></p><p>  Administration of reveromycin A to osteoprotegerin-deficient knockout mice reduced tooth movement distances, increased bone volumes at the interradicular septum, decreased osteoclast counts, and reduced serum alkaline phosphatase and tartrate resistant acid phosphatase. Reveromycin A administration also caused a temporal shift in peak Runx2 staining in osteoprotegerin-deficient knockout mice so that the overall staining time course was similar to that observed for wild-type mice. </p><p> <strong>Conclusions</strong></p><p>  Reveromycin A administration in osteoprotegerin-deficient knockout mice inhibited bone resorption and normalized bone formation. As a result, normal bone turnover was obtained. </p><hr><p></p><p> <strong>Source: </strong>American Journal of Orthodontics & Dentofacial Orthopedics </p><p> <a href="http://www.ajodo.org/article/S0889-5406(13)00569-6/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-1848&slc_lang=fa&sid=1 Takahiro Yabumoto 10031947532846008703 10031947532846008703 No Department of Orthodontics, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan Ken Miyazawa 10031947532846008704 10031947532846008704 No Department of Orthodontics, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan Masako Tabuchi 10031947532846008705 10031947532846008705 Yes Department of Orthodontics, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan Satsuki Shoji 10031947532846008706 10031947532846008706 No Department of Orthodontics, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan Miyuki Tanaka 10031947532846008707 10031947532846008707 No Department of Orthodontics, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan Manami Kadota 10031947532846008708 10031947532846008708 No Department of Orthodontics, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan Mamoru Yoshizako 10031947532846008709 10031947532846008709 No Department of Orthodontics, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan Makoto Kawatani 10031947532846008710 10031947532846008710 No Antibiotics Laboratory, RIKEN, Saitama, Japan Hiroyuki Osada 10031947532846008711 10031947532846008711 No Antibiotics Laboratory, RIKEN, Saitama, Japan Hatsuhiko Maeda 10031947532846008712 10031947532846008712 No Department of Pathology, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan