fa Combined degenerative and regenerative remodeling responses of the mandibular condyle to experimentally induced disordered occlusion ارتودنسی Orthodontics پژوهشي Research <p> <strong>Introduction</strong></p><p>  The purposes of this research were to investigate the long-term responses of mandibular condylar cartilage to experimentally induced disordered occlusion and to evaluate changes in the expression of the SDF-1/CXCR4 axis. </p><p> <strong>Methods</strong></p><p> <strong> </strong>Experimentally induced disordered occlusions were created in 8-week-old female Sprague-Dawley rats by orthodontic methods. After 24 weeks, remodeling of the mandibular condylar cartilage was assessed by hematoxylin and eosin staining. Protein and mRNA expression of SDF-1, CXCR4, MMP9, IL6, OPG, and RANKL were investigated by means of immunohistochemical staining and real-time polymerase chain reaction. <strong></strong></p><p> <strong>Results</strong></p><p>  Obvious cartilage degenerative remodeling responses were observed they appeared as uneven distributions of cellular disposition, loss of cartilage surface integrity, and cell-free areas. Regenerative responses presenting as thickening of the whole and the calcified cartilage layers in the experimental group were also observed. Compared with the age-matched controls, the protein and mRNA levels of SDF-1, CXCR4, MMP9, IL6, and OPG, but not RANKL, were increased in the experimental group (all, P <0.05). In addition, the mRNA level of RANKL/OPG showed a decreasing trend in the experimental group compared with the age-matched controls (P = 0.052). </p><p> <strong>Conclusions</strong></p><p>  This study demonstrated that long-term experimentally induced disordered occlusion leads to a combined response in degeneration and regeneration of mandibular cartilage, accompanied by active interaction of the SDF-1/CXCR4 axis and local upregulation of MMP9, IL6, and OPG. </p><hr><p></p><p> <strong>Source: </strong>American Journal of Orthodontics & Dentofacial Orthopedics </p><p> <a href="http://www.ajodo.org/article/S0889-5406(12)00916-X/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-1724&slc_lang=fa&sid=1 Bin Kuang 10031947532846008122 10031947532846008122 No Department of Stomatology, First People's Hospital, Lanzhou, China Juan Dai 10031947532846008123 10031947532846008123 No Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China Qing-Yu Wang 10031947532846008124 10031947532846008124 No Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China Rong Song 10031947532846008125 10031947532846008125 No School of Stomatology, Lanzhou University, Lanzhou, China Kai Jiao 10031947532846008126 10031947532846008126 No Department of Oral Anatomy and Physiology and Temporomandibular Disorders, School of Stomatology, Fourth Military Medical University, Xi'an, China Jie Zhang 10031947532846008127 10031947532846008127 No Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China Xiao-Guang Tian 10031947532846008128 10031947532846008128 No Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China Yin-Zhong Duan 10031947532846008129 10031947532846008129 No Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China Mei-Qing Wang 10031947532846008130 10031947532846008130 Yes Department of Oral Anatomy and Physiology and Temporomandibular Disorders, School of Stomatology, Fourth Military Medical University, Xi'an, China