fa Highly aggressive human papillomavirus-related oropharyngeal cancer: clinical, radiologic, and pathologic characteristics پاتولوزی دهان، فک و صورت Oral and Maxillofacial Pathology پژوهشي Research <p> <strong>Objective</strong></p><p>  Although the majority of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinomas have a favorable prognosis, we search for markers of poor prognosis by carefully examining a subset of highly aggressive cases.</p><p> <strong> Study design</strong></p><p>  Seven patients with HPV-positive oropharyngeal cancer who presented with non-pulmonary distant metastasis or developed distant metastasis posttreatment were identified. Eight control cases were chosen which responded well to treatment. Pathologic and radiologic studies were reviewed and compared. </p><p> <strong>Results</strong></p><p> <strong> </strong>Two cases displayed a small cell carcinoma (SmCC) component upon pathologic review. Biomarker analysis revealed lower expression of NOTCH1 in the aggressive cohort in comparison to controls (P = .04). Cases showed a predominance of clustering of lymph nodes, extracapsular spread, and central tumor necrosis. </p><p> <strong>Conclusion</strong></p><p>  Although most HPV-related oropharyngeal cancers display a positive prognosis, it is evident that there is a subset, which behaves more aggressively. This early investigation identifies pathologic and radiologic features that may help to predict this behavior. </p><hr><p></p><p> <strong>Source: </strong>Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology </p><p> <a href="http://www.oooojournal.net/article/S2212-4403(13)00193-4/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-1708&slc_lang=fa&sid=1 Azeem S.Kaka 10031947532846008030 10031947532846008030 Yes Department of Otolaryngology, The Ohio State University Wexner Medical Center, OH, USA Bhavana Kumar 10031947532846008031 10031947532846008031 No Department of Otolaryngology, Division of Head and Neck Surgery and James Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, OH, USA Pawan Kumar 10031947532846008032 10031947532846008032 No Department of Otolaryngology, Division of Head and Neck Surgery and James Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, OH, USA Paul E.Wakely 10031947532846008033 10031947532846008033 No Department of Pathology, The Ohio State University Wexner Medical Center, OH, USA Claudia M.Kirsch 10031947532846008034 10031947532846008034 No Department of Radiology, Division of Neuroradiology, The Ohio State University Wexner Medical Center, OH, USA Mattew O.Old 10031947532846008035 10031947532846008035 No Department of Otolaryngology, Division of Head and Neck Surgery and James Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, OH, USA Enver Ozer 10031947532846008036 10031947532846008036 No Department of Otolaryngology, Division of Head and Neck Surgery and James Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, OH, USA Amit Agraval 10031947532846008037 10031947532846008037 No Department of Otolaryngology, Division of Head and Neck Surgery and James Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, OH, USA Ricardo E.Carrau 10031947532846008038 10031947532846008038 No Department of Otolaryngology, Division of Head and Neck Surgery and James Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, OH, USA David E.Schuller 10031947532846008039 10031947532846008039 No Department of Otolaryngology, Division of Head and Neck Surgery and James Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, OH, USA