fa WWP1 gene is a potential molecular target of human oral cancer پاتولوزی دهان، فک و صورت Oral and Maxillofacial Pathology پژوهشي Research <p> <strong>Objective</strong></p><p>  This study investigates the oncogenic role of WWP1, an ubiquitin ligase linked to tumor promotion, in oral cancer.</p><p> <strong> Study design</strong></p><p>  An array-based comparative genomic hybridization was used to detect chromosomal changes in 10 oral cancer specimens. An additional 59 specimens and 6 cultured oral cancer cells were further examined to evaluate changes in the DNA copy number and messenger RNA (mRNA) and protein expression of WWP1. </p><p> <strong>Results</strong></p><p>  The copy number of the WWP1 gene and its mRNA levels were significantly increased in the oral cancer specimens. An elevated WWP1 gene expression was observed in 6 cultured oral cancer cell lines. Knockdown of the endogenous WWP1 using small hairpin RNA further showed that deficiency of WWP1 suppressed cell growth and caused apoptosis in oral cancer cells. </p><p> <strong>Conclusion</strong> </p><p> Our results reveal that WWP1 might play an oncogenic role in oral cancer cells. </p><hr><p></p><p> <strong>Source: </strong>Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology </p><p> <a href="http://www.oooojournal.net/article/S2212-4403(13)00234-4/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-1685&slc_lang=fa&sid=1 Ju-Hwa Lin 10031947532846007925 10031947532846007925 Yes Department of Biological Science and Technology, China Medical University, Taichung, Taiwan Shu-Chen Hsieh 10031947532846007926 10031947532846007926 No Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan Jia-Ni Chen 10031947532846007927 10031947532846007927 No The PhD Program for Cancer Biology and Drug Discovery, China Medical University, Taichung, Taiwan Ming-Hsui Tsai 10031947532846007928 10031947532846007928 No Department of Otolaryngology, China Medical University Hospital, Taichung, Taiwan Chia-Che Chang 10031947532846007929 10031947532846007929 No Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan