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Oral ulcers in patients with advanced breast cancer receiving everolimus: a case series report on clinical presentation and management
بیماری های دهان
Oral Medicine
پژوهشي
Research
<p> <strong>Objective</strong></p><p> We report the clinical features and management outcomes in 7 patients with everolimus-related stomatitis. </p><p> <strong>Study design</strong></p><p> Fifteen women with hormone-receptor-positive advanced breast cancer receiving everolimus combined with exemestane were prospectively evaluated to assess the development of stomatitis. Oral ulcers were diagnosed based on established criteria. </p><p> <strong>Results</strong></p><p> Seven patients developed stomatitis (46.6%). All patients were treated with topical dexamethasone solution, while everolimus was temporarily discontinued in 4 patients. Stomatitis resolved within 1-2 weeks. Two of the 4 patients, who had interrupted everolimus, developed recurrent stomatitis following drug resume and everolimus was again discontinued and restarted after 2 weeks. To date, 5 patients receive everolimus in full dose. The 2 patients, who developed recurrent stomatitis, received a reduced dose.</p><p> <strong> Conclusions</strong></p><p> Everolimus-related oral ulcers were frequent and led to dose modifications. Controlled trials, endorsing a consensus in terminology, are needed to evaluate measures on prevention and management of this unique toxicity. </p><hr><p></p><p> <strong>Source: </strong>Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology </p><p> <a href="http://www.oooojournal.net/article/S2212-4403(13)00115-6/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p>
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http://idai.ir/browse.php?a_code=A-10-32-1682&slc_lang=fa&sid=1
Ourania
Nocolatou-Calitis
10031947532846007895
10031947532846007895
Yes
Clinic of Hospital Dentistry, Oral Oncology Unit, Dental School, University of Athens, Athens, Greece
Adamantia
Nikolaidi
10031947532846007896
10031947532846007896
No
Oncology Department, Mitera Hospital-Ygeia, Athens, Greece
Ilia
Athanassiadis
10031947532846007897
10031947532846007897
No
Oncology Department, Mitera Hospital-Ygeia, Athens, Greece
Erofili
Papadopoulou
10031947532846007898
10031947532846007898
No
Clinic of Hospital Dentistry, Oral Oncology Unit, Dental School, University of Athens, Athens, Greece
Stephen
Sonis
10031947532846007899
10031947532846007899
No
Division of Oral Medicine, Brigham and Women's Hospital, Boston, MA, USA