fa Clinical outcomes of radiation-based locoregional therapy in locally advanced head and neck squamous cell carcinoma patients not responding to induction chemotherapy بیماری های دهان Oral Medicine پژوهشي Research <p> <strong>Objective </strong></p><p> The purpose of this study was to evaluate the efficacy of radiation-based locoregional therapy for locally advanced head and neck squamous cell carcinoma (LA-HNSCC) patients who did not respond to induction chemotherapy (IC). </p><p> <strong>Study Design</strong></p><p>  Outcomes after radiation-based locoregional therapy were retrospectively analyzed. </p><p> <strong>Results</strong> </p><p> Among a total of 208 patients treated with IC, 46 (22.1%) did not respond. After IC, patients were treated with radiotherapy (RT), concurrent chemoradiotherapy (CCRT), or surgery with or without postoperative RT. Among the 46 nonresponders, 17 (37.8%) patients underwent surgery and 28 (62.2%) were treated with RT or CCRT. Responses to subsequent RT or CCRT for 26 evaluable patients were as follows: complete response=7 (26.9%), partial response=9 (34.6%), stable disease=4 (15.4%), and progressive disease=6 (23.1%). </p><p> <strong>Conclusion</strong></p><p>  A significant proportion of LA-HNSCC patients who did not respond to IC can benefit from subsequent RT or CCRT. </p><hr><p></p><p> <strong>Source: </strong>Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology </p><p> <a href="http://www.oooojournal.net/article/S2212-4403(13)00063-1/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-1657&slc_lang=fa&sid=1 Yoojoo Lim 10031947532846007769 10031947532846007769 Yes Department of Internal Medicine, Seoul National University Hospital Bhumsuk Kim 10031947532846007770 10031947532846007770 No Department of Internal Medicine, Seoul National University Hospital Youngil Koh 10031947532846007771 10031947532846007771 No Department of Internal Medicine, Seoul National University Hospital Tae Min Kim 10031947532846007772 10031947532846007772 No Department of Internal Medicine, Seoul National University Hospital Se-Hoon Lee 10031947532846007773 10031947532846007773 No Department of Internal Medicine, Seoul National University Hospital J.Huh Hah 10031947532846007774 10031947532846007774 No Department of Otorhinolaryngology, Seoul National University Hospital Tack-Kyun Kwon 10031947532846007775 10031947532846007775 No Department of Otorhinolaryngology, Seoul National University Hospital Dong-Wan Kim 10031947532846007776 10031947532846007776 No Department of Internal Medicine, Seoul National University Hospital Hong-Gyun Wu 10031947532846007777 10031947532846007777 No Department of Radiation Oncology, Seoul National University Hospital Myung-Whun Sung 10031947532846007778 10031947532846007778 No Department of Otorhinolaryngology, Seoul National University Hospital