fa Analysis of factors influencing the development of xerostomia during intensity-modulated radiotherapy بیماری های دهان Oral Medicine پژوهشي Research <p> <strong>Objectives </strong></p><p> Factors influencing xerostomia during intensity-modulated radiation therapy (IMRT) were assessed. </p><p> <strong>Methods</strong></p><p>  A 6-week study of 32 head and neck cancer (HNC) patients was performed. Subjects completed the Xerostomia Inventory (XI) and provided stimulated saliva (SS) at baseline, week 2 and at end of IMRT. Influence of SS flow rate (SSFR), calcium and mucin 5b (MUC5b) concentrations and radiation dose on xerostomia was determined. </p><p> <strong>Results</strong></p><p>  HNC subjects experienced mean SSFR decline of 36% by visit 2 (N = 27 P = .012) and 57% by visit 3 (N = 20 P = .0004). Concentrations of calcium and MUC5b increased, but not significantly during IMRT (P > .05). Xerostomia correlated most with decreasing salivary flow rate as determined by Spearman correlations (P < .04) and linear mixed models (P < .0001).</p><p> <strong> Conclusions</strong> </p><p> Although IMRT is sparing to the parotid glands, it has an early effect on SSFR and the constituents in saliva in a manner that is associated with the perception of xerostomia. </p><hr><p></p><p> <strong>Source: </strong>Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology </p><p> <a href="http://www.oooojournal.net/article/S2212-4403(13)00012-6/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-1633&slc_lang=fa&sid=1 Ken Randal 10031947532846007604 10031947532846007604 No Department of Oral Health Practice, Division of Oral Medicine, Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY, USA Jason Stevens 10031947532846007605 10031947532846007605 No Department of Oral Health Practice, Division of Oral Medicine, Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY, USA Juan Fernando Yepes 10031947532846007606 10031947532846007606 No Department of Oral Health Science, Division of Pediatric Dentistry, College of Dentistry, University of Kentucky, Lexington, KY, USA Marcus E.Randall 10031947532846007607 10031947532846007607 No Department of Radiation Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA Mahesh Kudrimoti 10031947532846007608 10031947532846007608 No Department of Radiation Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA Jonathan Feddock 10031947532846007609 10031947532846007609 No Department of Radiation Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA Jing Xi 10031947532846007610 10031947532846007610 No Department of Statistics, University of Kentucky, Lexington, KY, USA Richard J. Kryscio 10031947532846007611 10031947532846007611 No Department of Statistics, University of Kentucky, Lexington, KY, USA Craig S.Miller 10031947532846007612 10031947532846007612 Yes Department of Oral Health Practice, Division of Oral Medicine, Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY, USA