fa Therapeutic efficacy of plasmonic photothermal nanoparticles in hamster buccal pouch carcinoma بیماری های دهان Oral Medicine پژوهشي Research <p> <strong>Objectives </strong></p><p> The objective of this study was to assess the short-term effect of plasmonic photothermal therapy (PPTT) on induced hamster buccal pouch (HBP) carcinoma. </p><p> <strong>Study Design</strong></p><p>  Seventy-six Syrian golden male hamsters were used. The induced HBP carcinomas were directly injected with ∼30 nm gold nanospheres followed by 15 min laser exposure (PPTT). </p><p> <strong>Results</strong> </p><p> PPTT caused rapid growth cessation and dramatic decrease in tumor sizes after 4 weeks of treatment (P < .05) compared to controls. Microscopic and immunohistochemical examination of the tumor biopsies revealed significant differences in the cellular apoptotic index (AI) value and proliferating cell nuclear antigen (PCNA) immunoexpression in PPTT-treated tumor tissue sections compared to controls (P < .05). Survival probability of the treated animals was increased compared to controls (P < .05). </p><p> <strong>Conclusion</strong> </p><p> PPTT proved to be a successful method for treating superficially located HBP carcinomas. </p><hr><p></p><p> <strong>Source: </strong>Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology </p><p> <a href="http://www.oooojournal.net/article/S2212-4403(12)01760-9/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-1630&slc_lang=fa&sid=1 Marwa Mounir Afifi 10031947532846007584 10031947532846007584 Yes Department of Oral Pathology, Faculty of Dentistry, Alexandria University, Azarita, Alexandria, Egypt Sahar M.El.Sheikh 10031947532846007585 10031947532846007585 No Department of Oral Pathology, Faculty of Dentistry, Alexandria University, Azarita, Alexandria, Egypt Maha M.Abdelsalam 10031947532846007586 10031947532846007586 No Department of Oral Pathology, Faculty of Dentistry, Alexandria University, Azarita, Alexandria, Egypt Heba Lecturer 10031947532846007587 10031947532846007587 No Department of Oral Pathology, Faculty of Dentistry, Alexandria University, Azarita, Alexandria, Egypt Taissir A.Omar 10031947532846007588 10031947532846007588 No Department of Oral Pathology, Faculty of Dentistry, Alexandria University, Azarita, Alexandria, Egypt Maha El.Tantawi 10031947532846007589 10031947532846007589 No Department of Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Alexandria University, Azarita, Alexandria, Egypt Khaled M.Abdel-Razek 10031947532846007590 10031947532846007590 No Medical Research Institute, Alexandria University, Hadara, Alexandria, Egypt Mostafa Mohamed 10031947532846007591 10031947532846007591 No Department of Medical Biophysics, Medical Research Institute, Alexandria University, Hadara, Alexandria, Egypt