fa Association of high-risk human papillomavirus infection with oral epithelial dysplasia پاتولوزی دهان، فک و صورت Oral and Maxillofacial Pathology پژوهشي Research <p> <strong>Objective</strong></p><p>  The aim of this study was to evaluate cases of oral epithelial dysplasia for biologically significant human papillomavirus (HPV) infection. </p><p> <strong>Study Design</strong> </p><p> Forty consecutive cases of high-grade dysplasia and 37 cases of low-grade dysplasia were examined for p16INK4a expression by immunohistochemistry. High-risk HPV infection was assessed in p16-positive cases using in situ hybridization. Proliferation index was assessed with MIB-1 immunohistochemistry.</p><p> <strong> Results</strong> </p><p> Eleven of 40 high-grade dysplasias and one of 37 low-grade dysplasias were p16 positive. High-risk HPV was detected in seven cases of p16-positive high-grade dysplasia. The difference between high- and low-grade dysplasia was statistically significant (P = .01). HPV-positive high-grade dysplasias showed a distinctive histologic appearance and MIB-1 labeling pattern. Most high-risk HPV-positive cases were seen in the floor of mouth.</p><p> <strong> Conclusion</strong></p><p>  High-risk HPV was associated with a subset of cases of severe epithelial dysplasia/carcinoma in situ that demonstrated diffuse loss of squamous differentiation and a high proliferation index. </p><hr><p></p><p> <strong>Source: </strong>Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology </p><p> <a href="http://www.oooojournal.net/article/S2212-4403(13)00048-5/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-1589&slc_lang=fa&sid=1 Christina McCord 10031947532846007362 10031947532846007362 Yes Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada Jing Xu 10031947532846007363 10031947532846007363 No Applied Molecular Profiling Laboratory, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada Wei Xu 10031947532846007364 10031947532846007364 No Department of Biostatistics, University Health Network, Toronto, Ontario, Canada Xin Qiu 10031947532846007365 10031947532846007365 No Department of Biostatistics, University Health Network, Toronto, Ontario, Canada Richard John McComb 10031947532846007366 10031947532846007366 No Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada Bayardo Perez-Ordonez 10031947532846007367 10031947532846007367 No Department of Pathology, University Health Network, Toronto, Ontario, Canada