fa SIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patients پاتولوزی دهان، فک و صورت Oral and Maxillofacial Pathology پژوهشي Research <p> <strong>Objectives</strong></p><p>  SIRT1, class III histone deacetylase, has been described to be up-regulated in various malignancies. However, the opposite results have been reported in other malignancies. Therefore, we investigated SIRT1 expression to clarify its biological behavior and identify its usefulness as a biomarker for head and neck squamous cell carcinoma (HNSCC). </p><p> <strong>Study Design</strong></p><p>  SIRT1 expression was assessed by immunohistochemistry (IHC) conducted using samples from 437 consecutive HNSCC patients. Acetylated histone status and p53 expression were also examined.</p><p> <strong> Results and Conclusion</strong></p><p>  IHC revealed 79.6% staining of SIRT1 in HNSCC, while almost all normal tissues showed positive staining. SIRT1 expression predominated in cases involving patients aged >65 years, lymph node negative, and early clinical stage cases. It was positively and statistically correlated with expression of acetylated histone H3K9 and H4K16, but not with p53. Multivariate analyses revealed that expression of SIRT1 was an independent and good indicator of prognosis. </p><hr><p></p><p> <strong>Source: </strong>Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology </p><p> <a href="http://www.oooojournal.net/article/S2212-4403(12)01765-8/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-1561&slc_lang=fa&sid=1 Akira Nogouchi 10031947532846007222 10031947532846007222 No Department of Molecular Pathology, Graduate School of Medicine, Yokohama City University, Yokohama, Kanagawa, Japan Xiaohan Li 10031947532846007223 10031947532846007223 No Division of Pathology, Affiliated Shengjing Hospital of China Medical University, Shenyang, Liaoning, China Akira Kubota 10031947532846007224 10031947532846007224 No Section of Head and Neck Cancer, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan Keiji Kikuji 10031947532846007225 10031947532846007225 No Kanagawa Cancer Center Research Institute, Yokohama, Kanagawa, Japan Yoichi Kameda 10031947532846007226 10031947532846007226 No Section of Pathology, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan Hauchuan Zheng 10031947532846007227 10031947532846007227 No Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, Liaoning, China Yohei Miyagi 10031947532846007228 10031947532846007228 No Kanagawa Cancer Center Research Institute, Yokohama, Kanagawa, Japan Ichiro Aoki 10031947532846007229 10031947532846007229 No Department of Molecular Pathology, Graduate School of Medicine, Yokohama City University, Yokohama, Kanagawa, Japan Yasuo Takano 10031947532846007230 10031947532846007230 Yes Kanagawa Cancer Center Research Institute, Yokohama, Kanagawa, Japan