fa Rare diagnosis of IgG4-related systemic disease by lip biopsy in an international Sjögren syndrome registry بیماری های دهان Oral Medicine پژوهشي Research IgG4-related disease has been recently defined as a distinct clinic-pathologic entity, characterized by dense IgG-4 plasmacytic infiltration of diverse organs, fibrosis, and tumefactive lesions. Salivary and lacrimal glands are a target of this disease and, when affected, may clinically resemble Küttner tumor, Mikulicz disease, or orbital inflammatory pseudotumor. In some patients, the disease is systemic, with metachronous involvement of multiple organs, including the pancreas, aorta, kidneys, and biliary tract. We report a 66-year-old man who presented with salivary gland enlargement and severe salivary hypofunction and was diagnosed with IgG4-related disease on the basis of a labial salivary gland biopsy. Additional features of his illness included a marked peripheral eosinophilia, obstructive pulmonary disease, and lymphoplasmacytic aortitis. He was evaluated in the context of a research registry for Sjögren syndrome and was the only 1 of 2594 registrants with minor salivary gland histopathologic findings supportive of this diagnosis. <hr><p> <strong>Source: </strong>Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology </p><p> <a href="http://www.oooojournal.net/article/S2212-4403(12)01015-2/abstract" target="_blank"><font color="#0000ff">Full Text</font></a></p> 0 0 http://idai.ir/browse.php?a_code=A-10-32-1557&slc_lang=fa&sid=1 Alan N.Baer 10031947532846007193 10031947532846007193 Yes Department of Medicine (Rheumatology), Johns Hopkins University School of Medicine, Baltimore, Maryland Christine G.Gourin 10031947532846007194 10031947532846007194 No Department of Otolaryngology and Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland William H.Westra 10031947532846007195 10031947532846007195 No Departments of Pathology and Otolaryngology and Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland Darren P.Cox 10031947532846007196 10031947532846007196 No Department of Pathology, University of the Pacific School of Dentistry, San Francisco, California John S. Greenspan 10031947532846007197 10031947532846007197 No Departments of Orofacial Sciences and Pathology, Schools of Dentistry and Medicine, University of California, San Francisco, California Troy E. Daniels 10031947532846007198 10031947532846007198 No Departments of Orofacial Sciences and Pathology, Schools of Dentistry and Medicine, University of California, San Francisco, California